Results 211 to 220 of about 50,388 (308)

Six‐month follow‐up of ARIA‐H and iron deposition in real‐world lecanemab therapy for Alzheimer's disease: Evidence from a Chinese 7T MRI cohort

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION With the approval of lecanemab for treating Alzheimer's disease (AD), there is an urgent need to evaluate its safety and treatment effects on biomarkers in real‐world practice. METHODS Patients receiving lecanemab (n = 72) underwent routine 3T and 7T magnetic resonance imaging (MRI) for amyloid‐related imaging abnormality (ARIA ...
Weiwei Zhang, Haokun Liu, Cong Zhang, Yulai Li, Keying Fang, Yafang Zhou, Ling Weng, Liangjuan Fang, Yingying Luo, Han Xiao, Lin Zhou, Bin Jiao, Lu Shen   +12 more
wiley   +1 more source

Comparative Analysis of Two Autophagy-Enhancing Small Molecules (AUTEN-67 and -99) in a <i>Drosophila</i> Model of Spinocerebellar Ataxia Type 1. [PDF]

Int J Mol Sci
Burján T, Aslam M, Keresztes F, Sigmond T, Billes VA, Bencsik N, Schlett K, Vellai T, Kovács T.   +8 more
europepmc   +1 more source

Association between basal forebrain volume and age in the presenilin‐1 E280A autosomal dominant Alzheimer's disease kindred

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The basal forebrain (BF), a key cholinergic hub, undergoes atrophy in Alzheimer's disease (AD), contributing to cognitive decline. However, its age‐related differences and early vulnerability in autosomal dominant AD (ADAD) remain unclear.
Bing He, Paula Ospina Lopera, Alejandro Espinosa, Juan Camilo Becerra, Laura Osorio, Diana Alzate, Sergio Alvarez, Alice Grazia, Stefan J. Teipel, Vincent Malotaux, Catarina Tristão‐Pereira, Meredith C. Rowe, Averi Giudicessi, Yi Su, Yinghua Chen, Sonia Do Carmo, David Aguillón, A. Claudio Cuello, Yakeel T. Quiroz   +18 more
wiley   +1 more source

The cholinergic basal forebrain and its role in neurodegeneration. [PDF]

J Neuropathol Exp Neurol
Cykowski MD, Masdeu JC.
europepmc   +1 more source

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION In Alzheimer's disease (AD), females have higher prevalence and faster progression, but sex‐specific molecular findings in AD are limited. METHODS We comprehensively examined 6162 proteins in cerebrospinal fluid (CSF) from 2496 participants to identify sex‐specific proteomic alteration by CSF amyloid beta (Aβ)42 and phosphorylated
Anh N. Do, Soomin Song, Muhammad Ali, Jigyasha Timsina, Lihua Wang, Daniel Western, Menghan Liu, Jessie Sanford, Matitee Rosende‐Roca, Merce Boada, Raquel Puerta, Edward N. Wilson, Agustin Ruiz, Pau Pastor, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Tony Wyss‐Coray, Carlos Cruchaga, Yun Ju Sung   +17 more
wiley   +1 more source

Ras signaling in either prothoracic gland cells or cholinergic neurons of Drosophila melanogaster regulates fly size

, 2007
Philip E. Caldwell
openalex   +1 more source

Associations between metabolic syndrome and regional brain iron depositions and cognitive function in middle‐aged and older adults: A two multinational cohort study

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The alterations of regional brain iron in patients with metabolic syndrome (Mets) and its relationship with cognitive function remain unclear. METHODS These analyses utilized data from two prospective cohorts, from the UK Biobank (UKB) (21,346 participants) and from Jinan, China (224 participants). We capitalized brain iron in the
Xinyue Zhang, Linfeng Yang, Na Wang, Yuanyuan Wang, Qihao Zhang, Zhenyu Cheng, Yiwen Chen, Pengcheng Liang, Meng Li, Lingfei Guo, Changhu Liang   +10 more
wiley   +1 more source

Optogenetic dissection of cardiac autonomic balance: illuminating the heart's dialogue between nerves and myocytes. [PDF]

Am J Physiol Heart Circ Physiol
Lang D.
europepmc   +1 more source

Visuospatial dysfunction indicates an increased risk of rapid dementia conversion in Parkinson's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The aim of this study was to define cognitive subtypes of early‐stage Parkinson's disease (PD) based on temporal evolutionary patterns of domain‐specific decline. METHODS We retrospectively enrolled 474 patients with early‐stage PD who underwent detailed neuropsychological testing at initial assessment. Age‐ and education‐specific
Chan Wook Park, Youngseok Choi, Yeeun Sun, Hye Sun Lee, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Jeyeon Lee, Seok Jong Chung   +8 more
wiley   +1 more source

Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus. [PDF]

Physiol Rep
Kamijo TC, Karnup S, Matsuoka K, Kimura S, Miyazato M, Daugherty SL, Beckel JM, Yoshimura N.   +7 more
europepmc   +1 more source