Results 251 to 260 of about 50,388 (308)

Choline and Cholinergic Neurons

Science, 1983
Mammalian neurons can synthesize choline by methylating phosphatidylethanolamine and hydrolyzing the resulting phosphatidylcholine. This process is stimulated by catecholamines. The phosphatidylethanolamine is synthesized in part from phosphatidylserine; hence the amino acids methionine (acting after conversion to S
J K, Blusztajn, R J, Wurtman
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Mesopontine cholinergic and non-cholinergic neurons in schizophrenia

Neuroscience, 1999
Mesopontine cholinergic neurons influence midbrain dopaminergic neurons, and thalamic and cerebellar structures which have been implicated in the neuroanatomy of schizophrenia. It has been reported that there are approximately twice as many mesopontine cholinergic neurons in schizophrenics than in normals, using nicotinomide adenosine dinucleotide ...
D C, German, K F, Manaye, D, Wu, L B, Hersh, R M, Zweig   +4 more
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Dopaminergic Dependency of Cholinergic Pallidal Neurons

Neuroscience, 2023
We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most neurons were inactive, although approximately 20% displayed spontaneous firing, including burst firing.
Janintzitzic López-Niño, Montserrat Padilla-Orozco, Aidán Ortega, Verónica Alejandra Cáceres-Chávez, Dagoberto Tapia, Antonio Laville, Elvira Galarraga, José Bargas   +7 more
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Acetylcholinesterase and the cholinergic neuron

Life Sciences, 1979
Abstract While the distribution of AChE in the central nervous system remains largely unexplained, neurons with very high levels of AChE are frequently identified as cholinergic, and cholinergic neurons always have high levels of AChE. This supports the utility of the empirical rule, that identification of cholinergic neurons requires demonstration ...
J, Lehmann, H C, Fibiger
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Histamine depolarizes cholinergic septal neurons

Journal of Neurophysiology, 1996
1. Bath application of 10 microM histamine (HA) resulted in a depolarization or inward current in 58/59 cholinergic neurons located in the medial septum and nucleus of the diagonal band of Broca (MS/DBB) in a slice preparation of rat brain. 2. In bridge mode, the histamine-induced depolarization consisted of both fast and slow phases; inward currents ...
N, Gorelova, P B, Reiner
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β-Amyloid and Cholinergic Neurons

Neurochemical Research, 2003
It is generally accepted that the crucial events in the pathogeny of Alzheimer's disease (AD) are the increased accumulation of amyloidogenic peptides derived from amyloid precursor protein and the harmful actions of these peptides on neurons, which bring about neurodegeneration. The enhanced beta-amyloid accumulation is known to be caused by mutations
Vladimír, Dolezal, Jana, Kasparová
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From the cholinergic gene locus to the cholinergic neuron

Journal of Physiology-Paris, 1998
The cholinergic gene locus (CGL) was first identified in 1994 as the site (human chromosome 10q11.2) at which choline acetyltransferase and a functional vesicular acetylcholine transporter are co-localized. Here, we present recent neuroanatomical, developmental, and evolutionary insights into the chemical coding of cholinergic neurotransmission that ...
E, Weihe, M K, Schäfer, B, Schütz, M, Anlauf, C, Depboylu, C, Brett, L, Chen, L E, Eiden   +7 more
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The development of cholinergic neurons

Brain Research Reviews, 1988
Motoneuron precursors acquire some principles of their spatial organization early in their cell lineage, probably at the blastula stage. A predisposition to the cholinergic phenotype in motoneurons and some neural crest cells is detectable at the gastrula to neurula stages. Cholinergic expression is evident upon cessation of cell division.
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NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE

The Lancet, 1977
Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people.
P, White, C R, Hiley, M J, Goodhardt, L H, Carrasco, J P, Keet, I E, Williams, D M, Bowen   +6 more
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Distribution of AChE in cholinergic and non-cholinergic neurons

Brain Research, 1981
Intracellular and surface acetylcholinesterase activities were determined for individual cholinergic and non-cholinergic neurons dissected from the central nervous system of the leech. Echothiophate pretreatment was used to inhibit selectively extracellular enzyme.
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