Results 261 to 270 of about 50,388 (308)

Non-neuronal cholinergic airway epithelium biology

Current Opinion in Pharmacology, 2014
Acetylcholine, a major regulator of airway function, is not solely produced by neurons but also by a variety of non-neurons cells including various airway epithelial cells utilizing a molecular machinery of acetylcholine synthesis and release that differs from that of neurons.
Wolfgang, Kummer, Gabriela, Krasteva-Christ   +1 more
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The localization of central cholinergic neurons

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1986
Over the past decade our understanding of the localization of central cholinergic neurons has greatly increased. Interest in these systems has also intensified due to the involvement of cholinergic mechanisms in Alzheimer's disease. The distribution of central cholinergic neurons is reviewed, focusing on recent work in experimental animals.
S R, Vincent, K, Satoh, H C, Fibiger
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Cholinergic neurons in the human retina

Experimental Eye Research, 1987
Choline acetyltransferase (ChAT)-like immunoreactivity in the human retina can be demonstrated using a polyclonal antiserum to ChAT isolated from chick brain. There is a population of ChAT-like immunoreactive cells along both margins of the inner plexiform layer (IPL).
J B, Hutchins, J G, Hollyfield
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Dopaminergic Regulation of Septohippocampal Cholinergic Neurons

Journal of Neurochemistry, 1994
Abstract: The extent to which acetylcholine (ACh) release in the hippocampus is regulated by dopaminergic mechanisms was assessed using in vivo microdialysis in freely moving rats. Systemic administration of the dopamine (DA) receptor agonist apomorphine (1.0 mg/kg) or the specific D1 agonist CY 208–243 (1.0 mg/kg) increased microdialysate ...
J C, Day, H C, Fibiger
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The cholinergic neuronal phenotype in alzheimer′s disease

Metabolic Brain Disease, 2000
The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene.
J K, Blusztajn, B, Berse
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Biochemistry of Cholinergic Neurons

1975
The cholinergic system has not evoked the interest of psychopharmacologists to the same extent as the adrenergic or indoleaminergic systems of neurotransmission. It is not surprising that lay interest in hallucinogenesis has not included cholinergic agents such as the muscarinic drugs, because severe physiological reactions overlie their psychedelic ...
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Cholinergic responses in human neocortical neurones

1989
Neurones in deeper layers of slices of temporal or frontal human neocortex maintained in vitro were impaled with microelectrodes and responses to cholinergic agonists were studied under current and voltage clamp conditions. A range of membrane currents were identifiable: inactivating and persistent Na(+)-conductances, inactivating and persistent Ca2(+)-
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Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS

1986
Considerable information regarding the distribution of cholinergic neurons in the mammalian central nervous system has now been accumulated. This is due to the development of reliable markers for these cells. The most significant one is immunohistochemical staining for choline acetyltransferase (ChAT), the enzyme for acetylcholine synthesis.
P. L. McGeer, E. G. McGeer, H. Kimura, J.-F. Peng   +3 more
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Competitive Interactions between Developing Cholinergic Neurones

1979
Publisher Summary This chapter discusses the studies carried out on the chick ciliary ganglion to document critical interactions with the target tissue, which are necessary for survival and full maturation of cholinergic ganglion cells. Early ablation of the peripheral targets for these cholinergic parasympathetic neurons altered their development in
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Phospholipid methylation and cholinergic neurons

1982
The ability of cholinergic neurons to synthesize and release acetylcholine (ACh) depends, among other things, on their supply of choline (Ch) molecules. Several mechanisms are known to provide this choline, including the pathway described below: the de novo synthesis of phosphatidylcholine (PC) from phosphatidylethanolamine (PE), and its subsequent ...
Jan K Blusztajn, Steven H Zeisel, Richard J Wurtman   +2 more
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