Results 21 to 30 of about 50,388 (308)

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

Molecular Metabolism, 2015
Objective: Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis.
Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo   +7 more
doaj   +1 more source

Cerebral topography of vesicular cholinergic transporter changes in neurologically intact adults: A [18F]FEOBV PET study

Aging Brain, 2022
Acetylcholine plays a major role in brain cognitive and motor functions with regional cholinergic terminal loss common in several neurodegenerative disorders.
Prabesh Kanel, Sygrid van der Zee, Carlos A. Sanchez-Catasus, Robert A. Koeppe, Peter J.H. Scott, Teus van Laar, Roger L. Albin, Nicolaas I. Bohnen   +7 more
doaj   +1 more source

A cellular and regulatory map of the cholinergic nervous system of C. elegans

eLife, 2015
Nervous system maps are of critical importance for understanding how nervous systems develop and function. We systematically map here all cholinergic neuron types in the male and hermaphrodite C. elegans nervous system.
Laura Pereira, Paschalis Kratsios, Esther Serrano-Saiz, Hila Sheftel, Avi E Mayo, David H Hall, John G White, Brigitte LeBoeuf, L Rene Garcia, Uri Alon, Oliver Hobert   +10 more
doaj   +1 more source

Cholinergic and Neuroimmune Signaling Interact to Impact Adult Hippocampal Neurogenesis and Alcohol Pathology Across Development

Frontiers in Pharmacology, 2022
Alcohol (ethanol) use and misuse is a costly societal issue that can affect an individual across the lifespan. Alcohol use and misuse typically initiates during adolescence and generally continues into adulthood.
Victoria A. Macht, Ryan P. Vetreno, Ryan P. Vetreno, Fulton T. Crews, Fulton T. Crews, Fulton T. Crews   +5 more
doaj   +1 more source

Preferential cholinergic excitation of corticopontine neurons [PDF]

The Journal of Physiology, 2018
Key points Phasic activation of M1 muscarinic receptors generates transient inhibition followed by longer lasting excitation in neocortical pyramidal neurons ...
Arielle L. Baker, Ryan J. O’Toole, Allan T. Gulledge   +2 more
openalex   +4 more sources

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Journal of Pharmacological Sciences, 2007
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease.
Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si-Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi   +11 more
doaj   +1 more source

Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments

Journal of Ginseng Research, 2019
Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases.
Chen Chen, Haifeng Zhang, Hongliang Xu, Yake Zheng, Tianwen Wu, Yajun Lian   +5 more
doaj   +1 more source

The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning

Frontiers in Cellular Neuroscience, 2022
Modulation of neural circuits is essential for flexible sensory perception and decision-making in a changing environment. Cholinergic and GABAergic projections to the olfactory system from the horizontal limb of the diagonal band of Broca (HDB) in the ...
Ping Zhou, Penglai Liu, Ying Zhang, Dejuan Wang, Anan Li   +4 more
doaj   +1 more source

Cholinergic forebrain degeneration in the APPswe/PS1ΔE9 transgenic mouse

Neurobiology of Disease, 2007
The impact of Aβ deposition upon cholinergic intrinsic cortical and striatal, as well as basal forebrain long projection neuronal systems was qualitatively and quantitatively evaluated in young (2–6 months) and middle-aged (10–16 months) APPswe/PS1ΔE9 ...
Sylvia E. Perez, Saleem Dar, Milos D. Ikonomovic, Steven T. DeKosky, Elliott J. Mufson   +4 more
doaj   +1 more source

Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis

Translational Psychiatry, 2022
Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder.
Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael MacKinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan   +9 more
doaj   +1 more source