Results 111 to 120 of about 87,987 (161)

Cholinergic Receptors and Addiction

2020
Human behavior can be controlled by physical or psychological dependencies associated with addiction. One of the most insidious addictions in our society is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. These nicotinic
Roger L, Papke, Darlene H, Brunzell, Mariella, De Biasi   +2 more
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Cholinergic receptors in corpora cavernosa

Urology, 1984
In a group of 13 patients who underwent penile surgery, a small amount of cavernosal tissue was removed and examined for content of cholinergic receptors. Three patients did not display any amount of cholinergic receptors. Values in the other 10 patients ranged from 34 to 136 femtomols.
C J, Godec, H, Bates
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Studies on the nature of the cholinergic receptor

European Journal of Pharmacology, 1968
Abstract The effects of a number of proteolytic enzymes on the acetylcholine sensitivity of the chronically deniervated musue membrane and on the cholinesterase activity of the innervated end-plate were examined. None of the enzymes affected the acetylcholine sensitivity, but all of them inactivated cholinesterase.
E X, Albuquerque, M D, Sokoll, B, Sonesson, S, Thesleff   +3 more
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Cholinergic innervation and receptors in the cerebellum.

Progress in brain research, 1997
We have studied the source and ultrastructural characteristics of ChAT-immunoreactive fibers in the cerebellum of the rat, and the distribution of muscarinic and nicotinic receptors in the cerebellum of the rat, rabbit, cat and monkey, in order to define which of the cerebellar afferents may use ACh as a neurotransmitter, what target structures are ...
Jaarsma, Dick, Ruigrok, Tom, Caffe, AR, Cozzari, C, Levey, AI, Mugnaini, E, Voogd, J (Jan)   +6 more
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Immunohistochemistry of cholinergic receptors

Anatomy and Embryology, 1992
Acetylcholine and its receptors are involved in a variety of important signal transduction processes. As shown here paradigmatically for the human neuromuscular junction and the cerebral cortex, acetylcholine receptors can be visualized immunohistochemically at the cellular and subcellular level under physiological and pathological conditions.
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Presynaptic muscarinic cholinergic receptors

Nature, 1978
IN the isolated rabbit heart, acetylcholine inhibits the release of noradrenaline evoked by nicotinic drugs1, by KCl (ref. 2) and by sympathetic nerve stimulation3. The release of noradrenaline in response to sympathetic nerve stimulation in the rabbit heart was found to be reduced by para-sympathomimetic agonists, and atropine antagonised this effect ...
V K, Sharma, S P, Banerjee
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Cholinergic receptors and neurodegenerative diseases

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary This chapter focuses on cholinergic receptors and neurodegenerative diseases. Known as the “cholinergic hypothesis of Alzheimer's disease (AD),” this hypothesis has served as the main rationale for the development of anti-AD drugs, even if alternative approaches, such as the use of neurotrophic agents, nootropics, glutamate ...
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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
M V, Drake, J J, O'Donnell, J R, Polansky   +2 more
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The nicotinic cholinergic receptor: A theoretical model

Journal of Neuroscience Research, 1996
Based on published affinity-labeling and mutagenesis experiments describing the effect of changes in specific amino acids in molecular biological studies on the nicotinic acetylcholinergic receptor (nAChR), we have identified 12 amino acids which are important in functioning at the nicotinic cholinergic receptor.
M H, Aprison, E, Galvez-Ruano, K B, Lipkowitz   +2 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues

Journal of Ocular Pharmacology and Therapeutics, 1985
Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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