Results 121 to 130 of about 87,987 (161)

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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Cholinergic Receptors in the Human vas Deferens

Journal of Receptor Research, 1992
This study represents the first investigation demonstrating the contractile response to exogenous acetylcholine (ACh) in the isolated human vas deferens. Pharmacological characterization of cholinergic receptors was achieved using selective antagonists to define receptor subtypes.
H F, Miranda, D, Bustamante, O, Castillo, P, Salvatierra, H, Saavedra, E, Fernandez, C, Paeile, T, Pelissier, G, Pinardi   +8 more
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Cholinergic Receptor Isolation

1981
The isolation of specific cholinergic bindin protein (acetylcholine receptor = AChR) has been achieved successfully by numerous research groups (1-4, 7-9, 11, 12). The ideal source for such preparations was the electric organ of several species of Torpedo.
W. H. Hopff, A. A. Hofmann, G. Riggio, P. G. Waser   +3 more
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Cholinergic receptors in the Aplysia gill

Journal of Neurobiology, 1984
AbstractAcetylcholine has been suggested as a neurotransmitter released in the Aplysia gill by peripheral afferents of central neurons and by peripheral neurons within the gill. The perfused gill, isolated from the abdominal ganglion, was examined. At concentrations greater than 1 μM, acetylcholine elicited a slowly developing tonic contraction of the ...
S, Weiss, J I, Goldberg, J P, Edstrom, K, Lukowiak   +3 more
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Cholinergic receptors in insects

Trends in Biochemical Sciences, 1979
Abstract It has been suggested that cholinergic receptors in insects are neither nicotinic nor muscarinic but of a mixed nature, and hence differ from ‘classic' vertebrate receptors. However, recent evidence indicates that insects also contain distinct nicotinic and muscarinic binding-sites with properties resembling those of vertebrate receptors. The
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Cholinergic muscarinic receptors in rat cochlea

Brain Research, 1988
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers.
Y J, van Megen, A B, Klaassen, J F, Rodrigues de Miranda, W, Kuijpers   +3 more
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Muscarinic cholinergic receptors in goldfish retina

Life Sciences, 1979
Abstract Using 3 H-Quinuclinidyl Benzilate ( 3 H-QNB) as a high affinity ligand for quantitative studies of specific binding to muscarinic cholinergic receptors we have demonstrated the presence of such receptors in homogenates of goldfish retina. Only one set of binding sites could be detected with an apparent dissociation constant of 1.9 × 10 −10
J A, Moreno-Yanes, H R, Mahler
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Affinity Chromatography of Cholinergic Receptor Proteins

Journal of Receptor Research, 1984
Cholinergic binding proteins were purified from torpedo electric organ. The preparation comprises: solubilization by non-ionic detergents followed by unspecific prepurification. For prepurification the double reversed technique proved to be very useful. Finally we applied affinity chromatography.
W H, Hopff, D M, Bodmer, P G, Waser
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The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors

1986
Cholinergic synapses in brain undergo dynamic changes during development, maturation and aging. During the life span we can assume that there is a continuous interregulation between presynaptic and postsynaptic activity. In recent years several investigators have shown for example that both muscarine- and nicotine-like receptor binding sites in brain ...
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Nicotinic cholinergic receptors in brain synaptosomes

Brain Research, 1979
In order to elucidate pharmacological characteristics of nicotinic receptors in the brain, competitive binding of nicotine analogues or cholinergic agents to brain particles was studied utilizing [3H]nicotine. The binding of [3H]nicotine to brain crude nitochondrial or synaptosomal fraction was progressively inhibited by the addition of increasing ...
K, Yoshida, H, Imura
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