Results 151 to 160 of about 146,010 (350)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen   +2 more
wiley   +1 more source

Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens

open access: yesFrontiers in Physiology
The aim of this study was to evaluate the effect of the cholinergic receptor antagonists on ghrelin (GHRL) expression and release from parts of the gastrointestinal system in an unique animal model—newly hatched chickens.
Colin Guy Scanes   +2 more
doaj   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto   +12 more
wiley   +1 more source

Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption. [PDF]

open access: yesNeuropsychopharmacology, 2020
Wang J   +12 more
europepmc   +1 more source

Libidibia ferreaMature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway: Possible Involvement of Opioid and Cholinergic Receptors

open access: hybrid, 2014
Luis Armando Sawada   +6 more
openalex   +1 more source

Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors [PDF]

open access: gold, 2018
Katherine R. Brimblecombe   +5 more
openalex   +1 more source

Prenatal Diagnosis of MSL2‐Related Ventriculomegaly in Association With an Inherited 15q13 Microduplication

open access: yesClinical Genetics, EarlyView.
We hereby report the first prenatal diagnosis of MSL2‐related pathology, namely ventriculomegaly. Favorable 11‐month follow‐up illustrates the challenges in predicting postnatal outcomes for genetic anomalies linked to recently characterized phenotypes with limited documented cases.
Omar Zgheib   +12 more
wiley   +1 more source

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

open access: hybrid, 1977
Gregory A. Weiland   +4 more
openalex   +1 more source

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