Results 151 to 160 of about 2,429,018 (397)
Movement Disorders, EarlyView.ABSTRACT Background Parkinson's disease (PD) varies widely across individuals in clinical manifestations and course of progression. Identification of distinct biological subtypes could explain this heterogeneity, identify its pathophysiology, and predict disease progression. Objectives Our aim was to compare longitudinal clinical trajectories and brain
Seyed‐Mohammad Fereshtehnejad +7 more
wiley +1 more source
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, EarlyView.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011 The aim of review. To demonstrate value of disorders of cholinergic innervation in pathogenesis of irritable bowel syndrome (IBS).Original positions. The important place in regulation of gastro-intestinal tract functions belongs not only to M-, but also ...
Yu. O. Shulpekova
doaj
Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor [PDF]
, 1985 K.A. Frey +3 more
openalex +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar +4 more
wiley +1 more source
PLoS ONE, 2019 In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter +3 more
doaj +1 more source
Cholinergic modulation of an acetylcholine receptor-like antigen on the surface of chick ciliary ganglion neurons in cell culture [PDF]
, 1986 MA Smith +4 more
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ChemistryOpen, EarlyView.Two new 2,2′‐bipyridine‐4,4′‐dicarboxamide ligands and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. The L2‐Co complex shows strong antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Hussein Alchurak +5 more
wiley +1 more source
Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]
, 2009 These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang +5 more
core
Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide
Pest Management Science, EarlyView.Selective editing out of an insect gut protease cleavage site renders a spider‐derived insecticidal peptide active by ingestion by insect pests. Abstract BACKGROUND The toxin peptide U1‐AGTX‐Ta1b from the Hobo spider, Eratigena agrestis (Walckenaer, 1802), was studied to determine its potential to serve as a bioinsecticide.
Breck R. Davis +12 more
wiley +1 more source