Results 161 to 170 of about 2,497,858 (389)

The potentiating effect of TA-0910, a new TRH analog, on the central muscarinic cholinergic system is probably in part due to its inhibition of desensitization of muscarinic acetyicholine receptors

, 1990
Yukitsuka Kudo, Hiroshi Sumikawa, Ryuichi Ishida   +2 more
openalex   +1 more source

Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors [PDF]

, 2019
Filipe Nascimento, Lennart R. B. Spindler, Gareth B. Miles   +2 more
openalex   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients - A validation study in plasma and cerebrospinal fluid from two Swedish cohorts. [PDF]

Brain Behav Immun Health, 2020
Bynke A, Julin P, Gottfries CG, Heidecke H, Scheibenbogen C, Bergquist J.   +5 more
europepmc   +1 more source

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

, 2017
Thomas Papouin, Jaclyn M. Dunphy, Michaela Tolman, Kelly T. Dineley, Philip G. Haydon   +4 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

, 1977
Gregory A. Weiland, Barla Georgia, S.E. Lappi, Colin F. Chignell, Palmer Taylor   +4 more
openalex   +1 more source

D₂Dopamine Receptor-Mediated Modulation of Voltage-Dependent Na⁺Channels Reduces Autonomous Activity in Striatal Cholinergic Interneurons [PDF]

, 2004
Nicolas Maurice, Jeff Mercer, C. Savio Chan, Salvador Hernández‐López, Joshua Held, Tatiana Tkatch, D. James Surmeier   +6 more
openalex   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens

Frontiers in Physiology
The aim of this study was to evaluate the effect of the cholinergic receptor antagonists on ghrelin (GHRL) expression and release from parts of the gastrointestinal system in an unique animal model—newly hatched chickens.
Colin Guy Scanes, Klaudia Jaszcza, Krystyna Pierzchala-Koziec   +2 more
doaj   +1 more source