Results 301 to 310 of about 146,010 (350)

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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Cholinergic Receptor Isolation

1981
The isolation of specific cholinergic bindin protein (acetylcholine receptor = AChR) has been achieved successfully by numerous research groups (1-4, 7-9, 11, 12). The ideal source for such preparations was the electric organ of several species of Torpedo.
W. H. Hopff, A. A. Hofmann, G. Riggio, P. G. Waser   +3 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues

Journal of Ocular Pharmacology and Therapeutics, 1985
Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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Cholinergic transmission regulates extrajunctional acetylcholine receptors

Experimental Neurology, 1980
To determine the role of ACh transmission in the regulation of extrajunctional ACh receptors, we compared the effect of postsynaptic cholinergic blockade with that of surgical denervation. Blockade of ACh transmission was produced in the soleus muscles of rats by continuous local infusion of α-bungarotoxin, delivered by implantable osmotic pumps ...
A, Pestronk, D B, Drachman, E F, Stanley, D L, Price, J W, Griffin   +4 more
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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
M V, Drake, J J, O'Donnell, J R, Polansky   +2 more
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Cholinergic receptors in insects

Trends in Biochemical Sciences, 1979
Abstract It has been suggested that cholinergic receptors in insects are neither nicotinic nor muscarinic but of a mixed nature, and hence differ from ‘classic' vertebrate receptors. However, recent evidence indicates that insects also contain distinct nicotinic and muscarinic binding-sites with properties resembling those of vertebrate receptors. The
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Muscarinic cholinergic receptors in goldfish retina

Life Sciences, 1979
Abstract Using 3 H-Quinuclinidyl Benzilate ( 3 H-QNB) as a high affinity ligand for quantitative studies of specific binding to muscarinic cholinergic receptors we have demonstrated the presence of such receptors in homogenates of goldfish retina. Only one set of binding sites could be detected with an apparent dissociation constant of 1.9 × 10 −10
J A, Moreno-Yanes, H R, Mahler
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Cholinergic muscarinic receptors in rat cochlea

Brain Research, 1988
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers.
Y J, van Megen, A B, Klaassen, J F, Rodrigues de Miranda, W, Kuijpers   +3 more
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Affinity Chromatography of Cholinergic Receptor Proteins

Journal of Receptor Research, 1984
Cholinergic binding proteins were purified from torpedo electric organ. The preparation comprises: solubilization by non-ionic detergents followed by unspecific prepurification. For prepurification the double reversed technique proved to be very useful. Finally we applied affinity chromatography.
W H, Hopff, D M, Bodmer, P G, Waser
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Nicotinic cholinergic receptors in brain synaptosomes

Brain Research, 1979
In order to elucidate pharmacological characteristics of nicotinic receptors in the brain, competitive binding of nicotine analogues or cholinergic agents to brain particles was studied utilizing [3H]nicotine. The binding of [3H]nicotine to brain crude nitochondrial or synaptosomal fraction was progressively inhibited by the addition of increasing ...
K, Yoshida, H, Imura
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