Results 321 to 330 of about 2,497,858 (389)

Cholinergic receptors in corpora cavernosa

Urology, 1984
In a group of 13 patients who underwent penile surgery, a small amount of cavernosal tissue was removed and examined for content of cholinergic receptors. Three patients did not display any amount of cholinergic receptors. Values in the other 10 patients ranged from 34 to 136 femtomols.
C J, Godec, H, Bates
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Cholinergic receptors and neurodegenerative diseases

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary This chapter focuses on cholinergic receptors and neurodegenerative diseases. Known as the “cholinergic hypothesis of Alzheimer's disease (AD),” this hypothesis has served as the main rationale for the development of anti-AD drugs, even if alternative approaches, such as the use of neurotrophic agents, nootropics, glutamate ...
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Immunohistochemistry of cholinergic receptors

Anatomy and Embryology, 1992
Acetylcholine and its receptors are involved in a variety of important signal transduction processes. As shown here paradigmatically for the human neuromuscular junction and the cerebral cortex, acetylcholine receptors can be visualized immunohistochemically at the cellular and subcellular level under physiological and pathological conditions.
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Muscarinic cholinergic receptor heterogeneity

Trends in Neurosciences, 1982
Abstract The relatively recent application of receptor binding techniques to muscarinic receptor pharmacology has provided new data that generally confirm classical ideas about agonist-receptor interactions and competitive antagonism. However, additional information regarding muscarinic receptor heterogeneity has been provided through [ 3 H]ligand ...
Frederick J. Ehlert, William R. Roeske, Henry I. Yamamura   +2 more
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Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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Cholinergic Receptor Isolation

1981
The isolation of specific cholinergic bindin protein (acetylcholine receptor = AChR) has been achieved successfully by numerous research groups (1-4, 7-9, 11, 12). The ideal source for such preparations was the electric organ of several species of Torpedo.
W. H. Hopff, A. A. Hofmann, G. Riggio, P. G. Waser   +3 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues

Journal of Ocular Pharmacology and Therapeutics, 1985
Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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Cholinergic transmission regulates extrajunctional acetylcholine receptors

Experimental Neurology, 1980
To determine the role of ACh transmission in the regulation of extrajunctional ACh receptors, we compared the effect of postsynaptic cholinergic blockade with that of surgical denervation. Blockade of ACh transmission was produced in the soleus muscles of rats by continuous local infusion of α-bungarotoxin, delivered by implantable osmotic pumps ...
A, Pestronk, D B, Drachman, E F, Stanley, D L, Price, J W, Griffin   +4 more
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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
M V, Drake, J J, O'Donnell, J R, Polansky   +2 more
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Cholinergic receptors in insects

Trends in Biochemical Sciences, 1979
Abstract It has been suggested that cholinergic receptors in insects are neither nicotinic nor muscarinic but of a mixed nature, and hence differ from ‘classic' vertebrate receptors. However, recent evidence indicates that insects also contain distinct nicotinic and muscarinic binding-sites with properties resembling those of vertebrate receptors. The
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