Results 341 to 350 of about 2,429,018 (397)

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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Cholinergic receptors in aging and Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1986
Although Alzheimer's disease (AD) is a disorder involving multiple neurotransmitter systems, the basal forebrain cholinergic system (Ch system) is severely and consistently affected in this condition. In both animals and man, the nature of age-associated alterations in the Ch system is unclear. In addition, available studies of cholinergic receptors in
Peter J. Whitehouse, Kin Sing Au
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Pharmacology of Acetylcholine and Cholinergic Receptors

2020
Acetylcholine is a neurotransmitter that plays a significant role in a variety of physiological functions. Cholinergic neurons synthesize, store, and release acetylcholine and are also responsible for sympathetic and parasympathetic responses of the autonomous nervous system.
Amal Al-Aboudi, Sarah Falah Kokaz, Sara Nidal Abed, Raghu Prasad Mailavaram, Yazan A. Bataineh, Nirupam Das, Pran Kishore Deb, Fatimah Amin Younes, Ruba Anwar Salou, Katharigatta N. Venugopala   +9 more
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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
James J. O'Donnell, Jon R. Polansky, Michael V. Drake   +2 more
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Cholinergic Receptors in the Human vas Deferens

Journal of Receptor Research, 1992
This study represents the first investigation demonstrating the contractile response to exogenous acetylcholine (ACh) in the isolated human vas deferens. Pharmacological characterization of cholinergic receptors was achieved using selective antagonists to define receptor subtypes.
Hugo F. Miranda, O. Castillo, E. Fernandez, C. Paeile, G. Pinardi, Teresa Pelissier, D. Bustamante, P. Salvatierra, Hernan Saavedra   +8 more
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Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors.

Biochemistry, 2002
Muscarinic cholinergic receptors can appear to be more numerous when labeled by [(3)H]quinuclidinylbenzilate (QNB) than by N-[(3)H]methylscopolamine (NMS).
P. S. Park, C. Sum, A. Pawagi, J. W. Wells   +3 more
semanticscholar   +1 more source

Muscarinic cholinergic receptors in goldfish retina

Life Sciences, 1979
Abstract Using 3 H-Quinuclinidyl Benzilate ( 3 H-QNB) as a high affinity ligand for quantitative studies of specific binding to muscarinic cholinergic receptors we have demonstrated the presence of such receptors in homogenates of goldfish retina. Only one set of binding sites could be detected with an apparent dissociation constant of 1.9 × 10 −10
Jose A. Moreno-Yanes, Henry R. Mahler
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Cholinergic muscarinic receptors in rat cochlea

Brain Research, 1988
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers.
Wim Kuijpers, J. F. Rodrigues De Miranda, Y.J.B. van Megen, A. B. M. Klaassen   +3 more
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Affinity Chromatography of Cholinergic Receptor Proteins

Journal of Receptor Research, 1984
Cholinergic binding proteins were purified from torpedo electric organ. The preparation comprises: solubilization by non-ionic detergents followed by unspecific prepurification. For prepurification the double reversed technique proved to be very useful. Finally we applied affinity chromatography.
W. H. Hopff, Peter G. Waser, D. M. Bodmer   +2 more
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Physiological and kinetic properties of cholinergic receptors activated by multiaction interneurons in buccal ganglia of Aplysia.

Journal of Neurophysiology, 1977
1. Neurons of Aplysia buccal ganglia contain three types of acetylcholine (ACh) receptors, each of which has been characterized by its sensitivity to inhibitors and kinetics of desensitization and by the properties of the conductance change it controls ...
D. Gardner, E. Kandel
semanticscholar   +1 more source