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Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.Fasudil perfusion in the NAc increased basal extracellular serotonin but not dopamine, and suppressed depolarization‐evoked release of both. In contrast, KD025 showed minimal effects on basal levels and selectively suppressed evoked serotonin release. ABSTRACT Recent studies have indicated that the Rho GTPase family and Rho‐kinases are associated with ...
Rinako Tanaka +8 more
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Pharmacological Incongruity of Lacosamide in the Management of Delirium Complicated by Ileus
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.Delirium involves neurotransmitter imbalances and disrupted neural networks. Although lacosamide may theoretically treat delirium by reducing neuronal hyperexcitability via sodium channel modulation, clinical evidence is lacking. Sodium channels in the enteric nervous system mean lacosamide can cause gastrointestinal dysmotility independent of ...
Takahiko Nagamine
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Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao +6 more
wiley +1 more source
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The cholinergic system and depression
Behavioural Brain Research, 2011Major depressive disorder is a severe psychiatric condition which forms a substantial burden to patients and society. Despite continuous efforts to unravel its etiology and pathophysiology, many questions remain. The majority of neurobiological research and classical pharmacotherapy regimens have approached this illness as the consequence of a failing ...
Girstautė, Dagytė +2 more
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The Cholinergic System in Aging
Gerontology, 1987A morphometric analysis of neuronal loss during normal aging was performed in the nucleus basalis Meynert complex of the basal forebrain (Nbm) (nucleus septi medialis, nucleus of Broca's diagonal band, nucleus basalis) and the ciliary ganglion, a peripheral cholinergic structure, in patients free of neurological and psychiatric illness.
V, Bigl +5 more
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Cholinergic system of the heart
Česká a slovenská farmacie, 2015The cholinergic system of the heart can be either of neuronal or non-neuronal origin. The neuronal cholinergic system in the heart is represented by preganglionic parasympathetic pathways, intracardiac parasympathetic ganglia and postganglionic parasympathetic neurons projecting to the atria, SA node and AV node.
Matej, Kučera, Anna, Hrabovská
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The cholinergic system and cancer
Seminars in Cancer Biology, 2008The finding that the cholinergic system may be present in non-neuromuscular cells and tissues was, at the beginning, not easily accepted by the scientific community (since 1970-1982). Today the entire set of cholinergic molecules and their functions in cell-to-cell communication, mediated by intracellular ion dynamics, is well-established.
Laura, Paleari +3 more
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Behavioural plasticity and the cholinergic system
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984Evidence for the involvement of the cholinergic system in behavioural plasticity is reviewed by considering three forms of behavioural plasticity: habituation, learning and memory, and tolerance development. Although the cholinergic system may modulate the response tendencies of an animal, it does not appear to be involved in the process of habituation.
D H Overstreet
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Cholinergic Systems and Cholinergic Pathology
1984The history and chemistry of acetylcholine as a neurotransmitter have been discussed in other chapters in this book. In this chapter we are concerned with the neuroanatomy of cholinergic systems, including the location and nature of the receptors, and with the apparent involvement of such systems in various neurological disorders.
Patrick L. McGeer, Edith G. McGeer
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Cannabinoids And The Cholinergic System
The Journal of Clinical Pharmacology, 1981Abstract: Δ9‐Tetrahydrocannabinol (THC) decreases EEG activation and causes slow waves in the cat. The EEG slow‐wave activity is accompanied by a concomitant decrease in acetylcholine release from the neocortex. The findings suggest that THC depresses the brain stem activating system. Large doses of Δ8‐ and Δ‐THC increase brain acetylcholine levels in
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