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Extraneuronal cholinergic system in lymphocytes
Pharmacology & Therapeutics, 2000Acetylcholine (ACh) is well known as a neurotransmitter in both the central and peripheral nervous systems in mammalian species. Both muscarinic and nicotinic ACh receptors have been identified in lymphocytes isolated from thymus, lymph node, spleen, and peripheral blood, and their stimulation by muscarinic and nicotinic agonists elicits a variety of ...
K, Kawashima, T, Fujii
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The cholinergic system and hippocampal plasticity
Behavioural Brain Research, 2011Acetylcholine is an essential excitatory neurotransmitter in the central nervous system and undertakes a vital role in cognitive function. Consequently, there is ample evidence to suggest the involvement of both nicotinic and muscarinic acetylcholine receptors in the modulation of synaptic plasticity, which is believed to be the molecular correlate of ...
Benjamin D, Drever +2 more
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Modulation of cholinergic systems by manganese
NeuroToxicology, 2007Information on changes in the central nervous system (CNS) cholinergic systems following exposure to manganese are considerably less extensive than that associated with other neurotransmitter systems. However, experimental and clinical evidence support the notion that cholinergic activity plays a key role in the pathophysiology of manganese-induced ...
Yoram, Finkelstein +2 more
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Developmental aspects of the cholinergic system
Behavioural Brain Research, 2011Beyond its importance in sustaining or modulating different aspects of the activity of the central nervous system (CNS), the cholinergic system plays important roles during development. In the current review, we focus on the developmental aspects associated with major components of the cholinergic system: Acetylcholine, choline acetyltransferase ...
Yael, Abreu-Villaça +2 more
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Cognition and modulation of the cholinergic system
The role of the cholinergic system in the mediation of an entire complex hierarchy of interdependent cognitive functions, from the maintenance of arousal, to directed attention, to decision-making and problem-solving, and to new learning and memory, has been exceptionally well-studied over the past four decades.Peter J, Snyder, Paul T, Maruff
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Function of cholinergic systems and epilepsy
Neuroscience and Behavioral Physiology, 1976Chemical transmitters of nervous impulses play an important role in the physiological functions of the brain [1–3]. The role of mediator systems in the development of pathological processes in the CNS and, in particular, in,the genesis and course of epilepsy is possible.
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Cholinergic and peptidergic systems in PSP
1994PSP is associated with a widespread cholinergic deficit likely corresponding to a loss in cholinergic neurons. The cholinergic damage dramatically affects the basal ganglia and specific cell groups of the mesencephalon and pons. This provides an anatomically defined basis for motor and supranuclear oculomotor syndromes characteristic of PSP.
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The Importance of the Cholinergic System in Neurourology
European Urology, 1998To discuss the parasympathetic cholinergic innervation of the bladder, urethra, prostate and penile erectile tissues, and its functional importance.Evaluation of published information.Release of acetylcholine and other transmitters from cholinergic nerves may mediate bladder contraction, urethral relaxation, prostatic secretion and penile erection ...
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Section I. The Cholinergic System
2005Publisher Summary This chapter explains the cholinergic system that consists of the muscarinic system and the nicotinic system. Muscarinic receptors occur in all layers in the neocortex and are also distributed in the rest of the brain. The brain contains several potassium channels that are modulated by the cholinergic system.
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The Effects of Caffeine on the Cholinergic System
Mini-Reviews in Medicinal Chemistry, 2014Caffeine is a secondary metabolite of tea and coffee plants. It is the active psychostimulant ingredient of widely consumed beverages, chocolate and some drugs as well. The major pathways for caffeine including interaction with adenosine receptors have been identified but caffeine has several minor pathways as well that remain poorly understood ...
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