Results 271 to 280 of about 198,632 (298)

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, EarlyView.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, EarlyView.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

A morphometric analysis of isolated Torpedo electric organ synaptic vesicles following stimulation. [PDF]

, 1990
Dowe, G., Fox, G., Koetting, D.
core  

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

The Journal of Physiology, EarlyView.
Abstract figure legend The present study identified two sub‐populations of gill oxygen sensing neuroepithelial cells (NECs) distinguishable by their stored neurotransmitters – serotonin (5‐hydroxytryptamine, 5‐HT) or acetylcholine (ACh). Using transgenic Tg(elavl3:GCaMP6s) zebrafish, which express an endogenous calcium reporter in neurons, we ...
Maddison Reed, Anthea A. Mavridis, Jan A. Mennigen, Michael G. Jonz   +3 more
wiley   +1 more source

Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we identify key intrinsic properties underlying the distinct biophysical signature of gamma motoneurons (blue): a motoneuron subtype that innervates intrafusal muscle fibres (orange) to adjust spindle afferent (black) sensitivity for detecting muscle length changes during movement.
Simon A. Sharples, Struan J. Nisbet, Matthew J. Broadhead, Dennis Bo Jensen, Francesca L. Sorrell, Claire F. Meehan, Gareth B. Miles   +6 more
wiley   +1 more source

Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : Implications for Alzheimer´s disease

, 2008
Mats Nilbratt
openalex   +1 more source

Pathophysiology of breathing following genetic and pharmacologic modulation of cholinergic system : development of an airflow analysis model by double chamber plethysmography

, 2018
Aurélie Nervo
openalex   +1 more source

Cognitive impairment induced by sevoflurane anesthesia is mediated by the cholinergic system after gastrointestinal surgery in older patients: A randomized, controlled trial. [PDF]

Ibrain
Liu XX, Yang QX, Guo Y, He M, Yu ZH, Tian Q, Zhu ZQ.   +6 more
europepmc   +1 more source

Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart

The Journal of Physiology, EarlyView.
Grace K. Nielsen, Reesa M. Wilcox, Han‐Jun Wang   +2 more
wiley   +1 more source