Results 81 to 90 of about 90,058 (326)

Mining electron density for functionally relevant protein polysterism in crystal structures. [PDF]

, 2010
This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins.
Fraser, James S, Jackson, Colin J
core   +3 more sources

Long‐Term Safety and Efficacy of Repeat Treatments with DaxibotulinumtoxinA in Cervical Dystonia: Results from the ASPEN‐Open‐Label Study

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background DaxibotulinumtoxinA (DAXI), a novel botulinum neurotoxin (BoNT) formulation, was shown to be safe, effective, and long‐lasting in the treatment of cervical dystonia (CD) over one treatment cycle in the phase 3, randomized, placebo‐controlled ASPEN‐1 trial.
Peter McAllister, Atul T. Patel, Marta Banach, Aaron Ellenbogen, Jaroslaw Slawek, Sebastian Paus, Hyder A. Jinnah, Virgilio Evidente, Todd M. Gross, Rashid Kazerooni, Conor J. Gallagher, David A. Hollander   +11 more
wiley   +1 more source

Evaluating Response to High-Dose 13.3 mg/24 h Rivastigmine Patch in Patients with Severe Alzheimer's Disease [PDF]

, 2015
AIMS: To identify factors predicting improvement/stabilization on the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) and investigate whether early treatment responses can predict long-term outcomes, during a ...
Farlow, Martin R., Islam, M. Zahur, Meng, Xiangyi, Sadowsky, Carl H., Velting, Drew M.   +4 more
core   +1 more source

HETEROZYGOTES FOR ATYPICAL CHOLINESTERASE

British Journal of Anaesthesia, 1982
Three hundred and thirty-two patients undergoing electroconvulsive therapy received thiopentone and suxamethonium. In 31 the duration of the apnoea was greater than an assumed upper limit of normal of 240 s. Eight of these patients proved, on biochemical grounds, to be heterozygotes for the atypical gene. The reason why the heterozygous state is rarely
H. Owen, A.R. Hunter
openaire   +3 more sources

Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. [PDF]

, 2009
Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function.
Clement, Clayton, De La Garza, Richard, London, Edythe D, Miotto, Karen, Newton, Thomas F, Sevak, Rajkumar J, Shoptaw, Steven, Swanson, Aimee-Noelle, Zorick, Todd   +8 more
core  

Health‐Related Quality of Life in Relation to the 5‐2‐1 Criteria in Parkinson's Disease in Sweden

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Device‐aided therapies (DAT) offer alternatives to oral or transdermal dopaminergic treatments in advanced Parkinson's disease (PD), where they can reduce motor fluctuations and dyskinesia and improve health‐related quality of life (HRQoL).
Frida Hjalte, Anna Gustafsson, Jenny Samuelsson, Filip Bergquist, Anders Johansson, Per Odin   +5 more
wiley   +1 more source

Latent acetylcholinesterase in secretory vesicles isolated from adrenal medulla [PDF]

, 1981
A new procedure is described for the preparation of highly purified and stable secretory vesicles from adrenal medulla. Two forms of acetylcholinesterase, a membrane bound form as well as a soluble form, were found within these vesicles.
Abbs, Anton, Bergmeyer, Blakeborough, Carty, Casey, Chubb, Chubb, Creutz, Dahl, Ekerdt, Ellman, Famborough, Farquar, Gratzl, Gratzl, Gratzl, Ingebretsen, Johnson, Laemmli, Lagercrantz, Leighton, Little, Lowry, Lowry, Meyer, Morris, Morris, Omaye, Palade, Rotundo, Rotundo, Schmidt, Smilowitz, Somogyi, Terland, Terland, Trifaro, Winkler   +38 more
core   +1 more source

The Mild Behavioral Impairment Checklist for Parkinson's Disease: An Ancillary Instrument in Cognitive Assessment

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Mild behavioral impairment (MBI) is a syndrome characterized by the later‐life onset of neuropsychiatric symptoms (NPS) and serves as a potential marker for dementia. In Parkinson's disease (PD), MBI has been associated with worse cognition, cortical atrophy, and altered connectivity.
Gabriel D. Pinilla‐Monsalve, Yuan P. Song, Alexandru Hanganu, Zahinoor Ismail, Oury Monchi   +4 more
wiley   +1 more source

Gambaran Kadar Cholinesterase Darah Petani Penyemprot Pestisida di Desa Minasa Baji Kab.maros [PDF]

, 2010
Cholinesterase is the enzyme existing in the body functioned to keep the muscle, tissues and nerves cell workable in harmony and organized. The decrease of cholinesterase can be influenced by 2 factors namely the internal factor and external factors. One
Rahim, M. R. (Muh), Russeng, S. S. (Syamsiar), Tampudu, S. (Sylpanus)   +2 more
core  

Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: Implication in peripheral inflammation [PDF]

, 2018
Multiple Sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, and both genetic and environmental factors contribute to the pathogenesis of the disease.
Costantini, Erica, D'Angelo, Chiara, D'Aurora, Marco, Di Bari, Maria, Di Nicola, Marta, Franchi, Sara, Galizia, Sabrina, Gasperini, Claudio, Gatta, Valentina, Orlando, Viviana, Reale, Marcella, Ruggieri, Serena, Stuppia, Liborio, Tata, Ada Maria   +13 more
core   +2 more sources