Results 41 to 50 of about 42,628 (216)

Cholinesterase Inhibitors: Structure of Eserine [PDF]

Nature, 1973
ESERINE (physostigmine) was first isolated from the Calabar bean in the latter half of the last century1, but it was not until much later that its activity on the heart was demonstrated to be due to inhibition of acetylcholinesterase2,3. It is one of the few compounds that are equally active as inhibitors of both true and pseudo-cholinesterase and has ...
T J, Petcher, P, Pauling
openaire   +2 more sources

In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor

Scientific Reports, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is growing rapidly among the elderly population around the world.
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson   +2 more
doaj   +1 more source

Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial [PDF]

, 2017
BACKGROUND/OBJECTIVES: Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to ...
Boustani, Malaz A., Callahan, Christopher M., Campbell, Noll L., Fowler, Nicole, Gao, Sujuan, Hendrie, Hugh C., Li, Lang, Perkins, Anthony J., Skaar, Todd C.   +8 more
core   +1 more source

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Biomedical Papers, 2015
Aims: The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies.
Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa   +4 more
doaj   +1 more source

Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents. [PDF]

, 2000
Acetylcholinesterase inhibitors (ChEIs) enhance neuronal transmission by increasing the availability of acetylcholine in muscarinic and nicotinic receptors.
A Grob, BJ Carroll, BJ Steinberg, CH Dyck van, D Kaufer, DE Giles, DJ Safer, DS Geldmacher, DS Janowsky, DS Janowsky, DS Janowsky, DS Janowsky, DW Rowntree, EF Willoughby, JC Morris, JL Cummings, JL Cummings, JM Cooney, JM Cooney, KL Davis, KL Lanctot, LJ Thal, M Rosler, MA Raskind, MA Raskind, MA Raskind, MB Bowers, MF Weiner, MS Mega, MS Mega, N Sitaram, PJ Goodnick, PN Tariot, PS Kishnani, RE Becker, RT Rubin, SC Risch, SP Hoopes, SP Wengel, SS Leong, T Burt, Tal Burt, WJ Burke, YM Greene   +43 more
core   +1 more source

Cholinesterase inhibitors from botanicals

Pharmacognosy Reviews, 2013
Alzheimer's disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and ...
Ahmed, Faiyaz, Ghalib, Raza Murad, Sasikala, P., Ahmed, K. K. Mueen   +3 more
openaire   +3 more sources

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

Chemistry Central Journal, 2012
Background Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments ...
Wang Yue-Hu, Wan Qin-Li, Gu Cheng-Ding, Luo Huai-Rong, Long Chun-Lin   +4 more
doaj   +1 more source

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]

, 2014
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Agbaba, D., Alcaro, S., Bautista-Aguilera, O.M., Chioua, M., De Andrés, L., Filipic, S., Marco-Contelles, J., Nikolic, K., Ortuso, F., Ramsay, R.R., Rodríguez-Franco, M.I., Samadi, A., Soriano, E., Yañez, M.   +13 more
core   +3 more sources