Results 41 to 50 of about 2,823,581 (316)

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

Biomolecules, 2019
Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning.
Gabriela Dumitrita Stanciu, Andrei Luca, Razvan Nicolae Rusu, Veronica Bild, Sorin Ioan Beschea Chiriac, Carmen Solcan, Walther Bild, Daniela Carmen Ababei   +7 more
doaj   +1 more source

Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study.

PLoS ONE, 2014
Patients with Alzheimer's disease after an initial response to cholinesterase inhibitors may complain a later lack of efficacy. This, in association with incident neuropsychiatric symptoms, may worsen patient quality of life.
Gianfranco Spalletta, Carlo Caltagirone, Alessandro Padovani, Sandro Sorbi, Mahmood Attar, Delia Colombo, Luca Cravello, E V O L U T I O N study Working Group   +7 more
doaj   +1 more source

Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta-analysis

Experimental and Therapeutic Medicine, 2018
Recently, several randomized controlled trials on the use of cholinesterase inhibitors or memantine as treatments for cognitive impairment in Parkinson's disease (CIND-PD), Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) were ...
Y. Meng, Panpan Wang, Yaxue Song, Jianhua Wang   +3 more
semanticscholar   +1 more source

Cholinesterases and Their Inhibitors

, 2022
The main focus of this section is to review the available information on ChEs (ChEs) and their inhibitors. The ChE enzymes cause damage to the cholinergic system by hydrolyzing the neurotransmitter acetylcholine (ACh). ChE inhibitors, playing an important role in the cholinergic system, are used in the treatment of Alzheimer’s disease (AD) because of ...
openaire   +2 more sources

The Phenolic Content and Bioactivity Assessment of Rubus sanctus Schreber Species with Potential for Food and Ethnopharmacological Uses

Chemistry &Biodiversity, EarlyView.
ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
wiley   +1 more source

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Biomedical Papers, 2015
Aims: The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies.
Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa   +4 more
doaj   +1 more source

In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor

Scientific Reports, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is growing rapidly among the elderly population around the world.
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson   +2 more
doaj   +1 more source

FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti‐Enzymatic, and Antifungal Properties Against Phytopathogens

Chemistry &Biodiversity, EarlyView.
Essential oil from Cinnamomum camphora leaves: Chemical profiling using FTIR analysis and bioactivity assessment for diverse bio‐pharmaceutical applications. ABSTRACT This study explores key biopharmaceutical properties of Cinnamomum camphora essential oil (EO), including antioxidant, anti‐enzymatic, and antifungal activities, and evaluates its minimum
Maroua Cheribot Cherif, Hicham Boughendjioua, Lucia Caputo, Ippolito Camele, Tarek Tahraoui, Vincenzo De Feo, Hazem S. Elshafie   +6 more
wiley   +1 more source

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Biomolecules, 2019
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration.
B. Svobodova, E. Mezeiova, Vendula Hepnarova, M. Hrabinová, Ľ. Múčková, T. Kobrlova, D. Jun, O. Soukup, M. Jimeno, J. Marco-Contelles, J. Korábečný   +10 more
semanticscholar   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source