Results 51 to 60 of about 25,099 (263)

Anti-cholinergic drug burden in patients with dementia increases after hospital admission: a multicentre cross-sectional study

BMC Geriatrics, 2022
Background Anticholinergic medications are drugs that block cholinergic transmission, either as their primary therapeutic action or as a secondary effect.
Annabelle Hook, Jessica L. Randall, Carla M. Grubb, Natalie Ellis, Jack Wellington, Aayushi Hemmad, Agisilaos Zerdelis, Andrew R. D. Winnett, Benjamin D. W. Geers, Bethany Sykes, Charlotte N. Auty, Cecilia Vinchenzo, Christiane E. Thorburn, Daniella Asogbon, Emily Granger, Heather Boagey, Juliet Raphael, Kajal Patel, Kartik Bhargava, Mary-Kate M. Dolley, Matthew J. Maden, Mehdin M. Shah, Qao M. Lee, Ratnaraj Vaidya, Simran Sehdev, Sneha Barai, Sophie Roche, Uzair Khalid, David A. Codling, Judith R. Harrison   +29 more
doaj   +1 more source

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Indira Garcia‐Cordero, Mohsen Hadian, Juan Camilo Vargas‐Gonzalez, Marta Monteiro, David Gold, Abeer Khoja, Alonso Morales‐Rivero, Blas Couto, David Tang‐Wai, Susan Fox, Gabor G. Kovacs, Anthony E. Lang, Maria Carmela Tartaglia   +12 more
wiley   +1 more source

In vitro and in silico cholinesterase inhibitory activities of aaptamine and derivatives from Aaptos suberitoides [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Marine sponges from the genus Aaptos produce compounds, often alkaloids, with a wide range of bioactivities. Aaptos suberitoides exhibits anticancer, antioxidant, antibacterial proteasome inhibitory, and receptor activator of NF-kappaB ligand ...
Suciati Suciati, Hanifa Rahma Putri, Kishneth Palaniveloo, Ong Kuan Hung, Mohammed Rizman-Idid, Aty Widyawaruyanti, Nitra Nuengchamnong, Nungruthai Suphrom, Rhesi Kristiana, I Wayan Mudianta, Mary George, Edwin Setiawan   +11 more
doaj   +1 more source

Difficulties in Diagnosing a Case of Myasthenia Crisis

Journal of Clinical and Biomedical Sciences, 2020
A 26 year old, female presented to EMD in severe respiratory distress. Patient had history of breathlessness since past one month with h/o intrauterine death 1month back .On further investigation it was found that anti acetylcholine receptor ...
Atishaya G V, Prabhakar K, Anitha A, Jithendra Chaitanya   +3 more
doaj   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Use of Cholinesterase Inhibitors in Non-Alzheimer’s Dementias [PDF]

, 2019
Non-Alzheimer’s dementias constitute 30% of all dementias and present with major cognitive and behavioral disturbances. Cholinesterase inhibitors improve memory by increasing brain acetylcholine levels and are approved symptomatic therapies for Alzheimer’
Noufi, Paul E., Grossberg, George Thomas, Khoury, Rita, Jeyakumar, Sajeeka   +3 more
core   +1 more source

Synthesis, X-Rays Analysis, Docking Study and Cholinesterase Inhibition Activity of 2,3-dihydroquinazolin-4(1H)-one Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
In search of potent cholinesterase inhibitors, we have carried out the synthesis and biologically evaluation of various benzaldehyde based 2,3-dihydroquinazolin-4(1H)-one derivatives.
Muhammad Sarfraz, Umer Rashid, Nargis Sultana, Muhammad Ilyas Tariq   +3 more
doaj  

Heterogenous Neuropathology in a Pedigree with RAB39B‐Related Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background In 2015, we reported a family with Parkinson's disease resulting from the RAB39B p.G192R (c.574G>A) variant. Since then, two affected brothers from the family have undergone autopsy. Objectives To characterize neuropathological findings, assess intracellular distribution of RAB39B protein, and examine the effect of p.G192R on α ...
Caitlin Latimer, Oswaldo Lorenzo‐Betancor, Dong‐Hui Chen, Kimmy Su, Marika Bogdani, Anna J. Park, Minsuh Kim, Joshua Weiss, Malia Callier, Ella H. Chiu, Sarah Fish, Jennifer L. Witt, Wendy H. Raskind, Marie Y. Davis, C. Dirk Keene, Cyrus P. Zabetian   +15 more
wiley   +1 more source

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model

, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Tikva Vogel, Kreuter, Jörg (Prof. Dr.), Sascha Wien, Zensi, Anja, Kufleitner, Jürgen, Jörg Kreuter, Wien, Sascha, Jürgen Kufleitner, Bungert, Judith, Wagner, Sylvia, Judith Bungert, Dadparvar, Miriam, Vogel, Tikva, Anja Zensi, Sylvia Wagner, Worek, Franz, Miriam Dadparvar, Hagen von Briesen, Briesen, Hagen von, Franz Worek   +19 more
core   +1 more source

Previous studies of correlation of neuroanatomical markers and response of cholinesterase inhibitors in Alzheimer’s disease.

, 2023
Previous studies of correlation of neuroanatomical markers and response of cholinesterase inhibitors in Alzheimer’s disease.
Chia-Ju Chou (14611466), Yi-Chien Liu (824581), Shu-Ching Wu (14611460), Cheng-Feng Ho (14611463), Li-Hua Lee (14992751), Wan-Lin Liang (14992754)   +5 more
core   +1 more source