Results 41 to 50 of about 22,708 (195)

Cholinesterase inhibitors from botanicals

Pharmacognosy Reviews, 2013
Alzheimer's disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and ...
Ahmed, Faiyaz, Ghalib, Raza Murad, Sasikala, P., Ahmed, K. K. Mueen   +3 more
openaire   +3 more sources

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Use of Inhibitors in Cholinesterase Histochemistry [PDF]

Nature, 1965
PRESENT-DAY histochemical methods for demonstrating cholinesterases require the use of inhibitors in order to distinguish between acetyl- (that is, true, or specific) cholinesterase (AChE) and butyryl- (non-specific) cholinesterase (ChE). The histochemical technique determines AChE and ChE together, so that if either enzyme is inhibited without the ...
openaire   +2 more sources

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Clinical Signs of Poisoning with Pyrethroid and Cholinesterase Inhibitors

مجله دانشکده پزشکی اصفهان, 2011
Background: Due to the similarities between clinical signs of toxicity with pyrethroids and cholinesterase inhibitors, if the mistake between these two was made and the patient was treatment with atropine, severe atropine poisoning and even death could ...
Farzad Gheshlaghi, Zohreh Sedighinia
doaj  

Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex

Journal of Pharmacological Sciences, 2019
Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat ...
Keisuke Obara, Saki Horiguchi, Toma Shimada, Takumi Ikarashi, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanaka   +7 more
doaj   +1 more source

Anti-cholinergic drug burden in patients with dementia increases after hospital admission: a multicentre cross-sectional study

BMC Geriatrics, 2022
Background Anticholinergic medications are drugs that block cholinergic transmission, either as their primary therapeutic action or as a secondary effect.
Annabelle Hook, Jessica L. Randall, Carla M. Grubb, Natalie Ellis, Jack Wellington, Aayushi Hemmad, Agisilaos Zerdelis, Andrew R. D. Winnett, Benjamin D. W. Geers, Bethany Sykes, Charlotte N. Auty, Cecilia Vinchenzo, Christiane E. Thorburn, Daniella Asogbon, Emily Granger, Heather Boagey, Juliet Raphael, Kajal Patel, Kartik Bhargava, Mary-Kate M. Dolley, Matthew J. Maden, Mehdin M. Shah, Qao M. Lee, Ratnaraj Vaidya, Simran Sehdev, Sneha Barai, Sophie Roche, Uzair Khalid, David A. Codling, Judith R. Harrison   +29 more
doaj   +1 more source

Cholinesterases and Their Inhibitors

, 2022
The main focus of this section is to review the available information on ChEs (ChEs) and their inhibitors. The ChE enzymes cause damage to the cholinergic system by hydrolyzing the neurotransmitter acetylcholine (ACh). ChE inhibitors, playing an important role in the cholinergic system, are used in the treatment of Alzheimer’s disease (AD) because of ...
openaire   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

In vitro and in silico cholinesterase inhibitory activities of aaptamine and derivatives from Aaptos suberitoides [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Marine sponges from the genus Aaptos produce compounds, often alkaloids, with a wide range of bioactivities. Aaptos suberitoides exhibits anticancer, antioxidant, antibacterial proteasome inhibitory, and receptor activator of NF-kappaB ligand ...
Suciati Suciati, Hanifa Rahma Putri, Kishneth Palaniveloo, Ong Kuan Hung, Mohammed Rizman-Idid, Aty Widyawaruyanti, Nitra Nuengchamnong, Nungruthai Suphrom, Rhesi Kristiana, I Wayan Mudianta, Mary George, Edwin Setiawan   +11 more
doaj   +1 more source