Results 21 to 30 of about 22,708 (195)

An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

Pharmaceuticals, 2023
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning.
Shah Alam Khan, Mohammad Jawaid Akhtar, Urvashee Gogoi, Dhanalekshmi Unnikrishnan Meenakshi, Aparoop Das   +4 more
doaj   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Metabolite profile and in vitro cholinesterase inhibitory activity of extract and fractions of Aaptos suberitoides [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Marine sources such as sponges have shown a significant impact on the drug development from nature. Metabolites isolated from sponges show diversity in terms of structural features and pharmacological properties.
Hanifa R. Putri, Rhesi Kristiana, I Wayan Mudianta, Edwin Setiawan, Aty Widyawaruyanti, Nitra Nuengchamnong, Nungruthai Suphrom, Suciati Suciati   +7 more
doaj   +1 more source

Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer’s disease dispensed by the Brazilian public health system – 2008 to 2014: a nation-wide analysis

Arquivos de Neuro-Psiquiatria
In light of the high cost of dementia treatment, there is legislation authorizing free distribution of cholinesterase inhibitors to those suffering from Alzheimer’s disease in Brazil.
Flávia Silva de Moraes, Mariana Lima Cerqueira de Souza, Giancarlo Lucchetti, Alessandra Lamas Granero Lucchetti   +3 more
doaj   +1 more source

Proline-Based Carbamates as Cholinesterase Inhibitors

Molecules, 2017
Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and
Hana Pizova, Marketa Havelkova, Pavel Bobal, Sarka Stepankova, Tereza Kauerova, Andrzej Bak, Peter Kollar, Violetta Kozik, Michal Oravec, Ales Imramovsky, Josef Jampilek   +10 more
doaj   +1 more source

Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates [PDF]

The Ukrainian Biochemical Journal, 2014
Specifically synthesized group of benzimid­azole derivatives possessing varying degrees of delocalization of the positive charge in the cation group of the molecule has been studied in order to search for potential cholinergically active compounds and to
N. E. Basova, B. N. Kormilitsyn, A. Yu. Perchenok,, E. V. Rozengart, V. S. Saakov, A. A. Suvorov   +5 more
doaj   +1 more source

Cholinesterase Inhibitors: Structure of Eserine [PDF]

Nature, 1973
ESERINE (physostigmine) was first isolated from the Calabar bean in the latter half of the last century1, but it was not until much later that its activity on the heart was demonstrated to be due to inhibition of acetylcholinesterase2,3. It is one of the few compounds that are equally active as inhibitors of both true and pseudo-cholinesterase and has ...
T J, Petcher, P, Pauling
openaire   +2 more sources

Computer-aided approach for the identification of lead molecules as the inhibitors of cholinesterase’s and monoamine oxidases: Novel target for the treatment of Alzheimer disease [PDF]

Journal of the Serbian Chemical Society
Molecular docking is a promising and reliable technology for the purpose of discovering lead compounds via virtual screening. In addition to allowing for the testing of a large number of compounds, it also allows for the determination of how the selected
Ejaz Syeda Abida, Aziz Mubashir, Fayyaz Ammara, Wani Tanveer A., Zargar Seema   +4 more
doaj   +1 more source

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

Biomolecules, 2019
Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning.
Gabriela Dumitrita Stanciu, Andrei Luca, Razvan Nicolae Rusu, Veronica Bild, Sorin Ioan Beschea Chiriac, Carmen Solcan, Walther Bild, Daniela Carmen Ababei   +7 more
doaj   +1 more source

Position Statement on Anti-Dementia Medication for Alzheimer’s Disease by Swiss Stakeholders

Clinical and Translational Neuroscience, 2021
The present document represents the position of Swiss health-care associations, clinical and research centers, research-supporting foundations, and the association Alzheimer Switzerland regarding the care of persons with dementia and Alzheimer’s disease.
Giovanni B Frisoni, Jean-Marie Annoni, Stefanie Becker, Tim Brockmann, Markus Buerge, Jean-François Démonet, Dan Georgescu, Anton Gietl, Ulrich Hemmeter, Stefan Klöppel, Thomas Leyhe, Andreas U Monsch, Franco Rogantini, Delphine Roulet Schwab, Egemen Savaskan, Karl Schaller, Armin von Gunten, Gabriel Gold   +17 more
doaj   +1 more source