Comptes Rendus. Chimie, 2022 In our previous research, some screened 1,3-thiazole fragments were found to be potent by inhibiting LPS-induced TNF$\alpha $ and IL-8 release with IC50 values in the $\mu $M range without cytotoxic activity.
Modrić, Marina +7 more
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Understanding Alzheimer disease
South African Family Practice, 2019 Alzheimer disease (AD) is a neurodegenerative disorder with an uncertain pathogenesis. It is characterised by symptoms of memory impairment, executive dysfunction and visuospatial impairment.
M. Vally, F. Kathrada
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Dried blood spots in toxicology : from the cradle to the grave? [PDF]
, 2012 About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized.
De Kesel, Pieter +3 more
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An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities
Pharmaceuticals, 2023 Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning.
Shah Alam Khan +4 more
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New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation [PDF]
, 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE).
Chiarotto, Isabella +9 more
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An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
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Cholinesterase inhibitors for delirium [PDF]
Cochrane Database of Systematic Reviews, 2005 Delirium is now the preferred term to describe acute confusional states. It is experienced by 10 to 30% of all hospital inpatients. Delirium is potentially reversible and is related to several adverse outcomes, including increased hospital length of stay, poor functional status, persistent cognitive impairment, need for institutional care and probably ...
R, Overshott, S, Karim, A, Burns
openaire +2 more sources
Metabolite profile and in vitro cholinesterase inhibitory activity of extract and fractions of Aaptos suberitoides [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Marine sources such as sponges have shown a significant impact on the drug development from nature. Metabolites isolated from sponges show diversity in terms of structural features and pharmacological properties.
Hanifa R. Putri +7 more
doaj +1 more source
Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]
, 2016 Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
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The 10-word learning task in the differential diagnosis of early Alzheimer's disease and elderly depression: a cross-sectional pilot study [PDF]
, 2010 Objectives: Identification of early Alzheimer's disease (AD) has become very important. Episodic memory tasks appear to have predictive power for indicating early AD. Deficits in encoding and storage processes that are characteristic of AD, however, must
D'Haenens, Ellen +6 more
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