Results 71 to 80 of about 22,708 (195)

A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce, Steven Balog, Rachel Gaither, Melissa R. Pfeiffer, Fiona Bhondoekhan, Brian R. Ott, Seth A. Margolis, Alison E. Curry, Andrew R. Zullo   +8 more
wiley   +1 more source

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Muhammed Oğuzhan Doğan, Begüm Nurpelin Sağlık Özkan, Abdullah Burak Karaduman, Sevgi Karakuş, Yusuf Özkay, Zafer Asım Kaplancıklı, Fatih Tok   +6 more
wiley   +1 more source

Perspectives from Alzheimer's Disease Research Centers site directors on the early steps and the lasting impact

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Since the groundbreaking work of Alois Alzheimer in the early 1900s, Alzheimer's disease research has evolved immensely, most notably with the establishment of the Alzheimer's Disease Research Centers (ADRC). Fueled by the vision and funding of the National Institute on Aging (NIA), ADRCs have created a legacy through their work standardizing ...
John H. Growdon, John C. Morris, Ronald C. Petersen, Mary Sano, Lon S. Schneider   +4 more
wiley   +1 more source

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +1 more source

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Mehri Salari, Arash Soltani, Masoud Etemadifar, Kamran Rezaei   +3 more
wiley   +1 more source

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

ChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay   +9 more
wiley   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

cholinesterase inhibitor

Citation: 'cholinesterase inhibitor' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15556 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil

Insect Molecular Biology, Volume 35, Issue 5, Page 526-540, October 2026.
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun, Jessica M. Sparrow, Cody W. Koloski, Bryan J. Cassone   +3 more
wiley   +1 more source

Trustwide Clinical Audit of Dementia Diagnosis: How Are Diagnoses Made and What Treatments Are Offered?

BJPsych Open
Aims: To assess variations in dementia treatment, diagnosis, and pathway practices across the memory services in Tees, Esk and Wear Valleys (TEWV) NHS Foundation Trust and how these compare to Trust and national policy.
Olusegun Sodiya, Oluwatosin Atewogboye, Roseline Ataria, Mani Krishnan, Rachael Raw   +4 more
doaj   +1 more source