Results 71 to 80 of about 41,567 (239)

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Consumption trends for specific drugs used to treat dementia in the region of Madrid (Spain) from 2002 to 2012

Neurología (English Edition), 2015
Introduction: Analysing drug consumption in large population groups lets us observe consumption trends and compare them between different settings. Objective: To analyse the time trends for consumption and costs of specific drugs used to treat dementia ...
M.C. de Hoyos-Alonso, E. Tapias-Merino, C.M. Meseguer Barros, M. Sánchez-Martínez, A. Otero   +4 more
doaj   +1 more source

Anticholinergic Medication Burden in Parkinson’s Disease Outpatients

Journal of Parkinson’s Disease, 2022
Background: Individuals with Parkinson’s disease (PD) may be especially vulnerable to future cognitive decline from anticholinergic medications. Objective: To characterize anticholinergic medication burden, determine the co-occurrence of anticholinergic ...
Huma Nawaz, Lana Sargent, Helengrace Quilon, Leslie J. Cloud, Claudia M. Testa, Jon D. Snider, Sarah K. Lageman, Mark S. Baron, Brian D. Berman, Kristin Zimmerman, Elvin T. Price, Nitai D. Mukhopadhyay, Matthew J. Barrett   +12 more
doaj   +1 more source

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology [PDF]

, 2017
The British Association for Psychopharmacology coordinated a meeting of experts to review and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As before, levels of evidence were rated using accepted standards which were
Burns, A, Holmes, C, Jones, M, Jones, R, Livingston, G, McKeith, I, Mittler, P, O'Brien, JT, Passmore, P, Ritchie, C, Robinson, L, Sampson, EL, Taylor, J-P, Thomas, A   +13 more
core   +2 more sources

Quantifying Population Reversibility of Sensor Performance in Multi‐Cycle Single‐Sensor Recovery Assay

Small, EarlyView.
Single‐walled carbon nanotubes (SWCNTs) are versatile optical nanosensors that can be imaged at the single‐sensor level to map biological processes. To translate such imaging into calibrated measurements, sensor recovery under repeated analyte exposures must be analyzed.
Geffen Rosenberg, Gili Bisker
wiley   +1 more source

Impact of geriatric comorbidity and polypharmacy on cholinesterase inhibitors prescribing in dementia [PDF]

, 2011
BACKGROUND: Although most guidelines recommend the use of cholinesterase inhibitors (ChEIs) for mild to moderate Alzheimer's Disease, only a small proportion of affected patients receive these drugs.
Falk Hoffmann, Hendrik van den Bussche, Birgitt Wiese, Gerhard Schön, Daniela Koller, Marion Eisele, Gerd Glaeske, Martin Scherer, Hanna Kaduszkiewicz   +8 more
core   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Rapid recovery of postnivolumab vemurafenib-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome after tocilizumab and infliximab administration [PDF]

, 2020
Background Immune checkpoint inhibitors such as nivolumab and targeted BRAF inhibitors have dramatically altered the treatment outcomes of metastatic melanoma over the past few years. Skin toxicity is the most common adverse event (AE) related to the
Maestro, Alessandra, Marcuzzi, Annalisa, Maximova, Natalia, Zanon, Davide   +3 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial [PDF]

, 2017
BACKGROUND/OBJECTIVES: Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to ...
Boustani, Malaz A., Callahan, Christopher M., Campbell, Noll L., Fowler, Nicole, Gao, Sujuan, Hendrie, Hugh C., Li, Lang, Perkins, Anthony J., Skaar, Todd C.   +8 more
core   +1 more source