Results 81 to 90 of about 25,099 (263)

Unraveling the impact of common medications on biomarker patterns in Alzheimer's disease and mild cognitive impairment

Journal of Alzheimer's Disease Reports
Background The aging global population faces significant challenges from Alzheimer's disease (AD). Metabolomics offers a non-invasive, cost-effective diagnostic alternative.
Kaitlyn Paez, Claire Kopachik, Ali Yilmaz, Sangeetha Vishweswaraiah, Nadia Ashrafi, Nazia Saiyed, Nicolette Monacelli, Ieva Kerseviciute, Juozas Gordevicius, Stacey Ruff, Amita Pai, Imam Khaled, Michael E Maddens, Stewart F Graham   +13 more
doaj   +1 more source

Burden and Risk Factors of CGM‐Detected Hypoglycemia in Older Adults With Type 2 Diabetes

Journal of the American Geriatrics Society, EarlyView.
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Michael Fang, Natalie Rula Daya, Yein Jeon, Justin B. Echouffo‐Tcheugui, B. Gwen Windham, Scott Zeger, Elizabeth Selvin   +6 more
wiley   +1 more source

Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors

In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series of hydrazone derivatives bearing piperidine rings have been designed and synthesized.
Tatar Yılmaz, Gizem, Baltaş, Nimet, Kaya, Süleyman, Koçyiğit-Kaymakçıoğlu, Bedia, Tok, Fatih, Çevik, Özge, Abas, Burçin İrem   +6 more
core   +1 more source

Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study. [PDF]

INTRODUCTION We aimed to assess the impact of cholinesterase inhibitors (ChEIs) and memantine on cognition, major adverse cardiovascular events (MACE) and mortality in dementia with Lewy bodies (DLB).
Ferreira, Daniel, Eriksdotter, M,, Elisabet, L, Westman, Eric,, Ferreira, D, Xu, Hong, Habich, Annegret,, Westman, E,, Ferreira, Daniel,, Eriksdotter, Maria,, Habich, Annegret, Habich, A,, Elisabet, Londos, Westman, Eric, Xu, H,, Eriksdotter, Maria, Xu, Hong,, Lund University., Elisabet, Londos,   +18 more
core   +1 more source

Potentiation Between Cholinesterase Inhibitors.

Experimental Biology and Medicine, 1958
SummaryOrganic phosphate insecticides EPN, malathion, chlorothion and phostex, in all possible paired combinations administered simultaneously to mice showed potentiation in their oral toxicities. Some potentiation was observed even when EPN was given 24 hours before malathion.
P, ROSENBERG, J M, COON
openaire   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

Natural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato, Lucia Caputo, Laura De Martino, Daniela Grulova, Barbara Borczak, Joanna Kapusta‐Duch, Vincenzo De Feo   +6 more
wiley   +1 more source

Use of cholinesterase inhibitors in elderly patients with clinical comorbidities

, 2008
Cholinesterase inhibitors such as donepezil, galantamine and rivastigmine are drugs indicated for treatment of hypocholinergic dementias, particularly Alzheimer's disease.
Thomaz,Débora Pereira, Cunha,Ulisses Gabriel de Vasconcelos, Marquete,Carolina Ribeiro, Balabram,Karine, Marino,Carolina Guerra   +4 more
core  

Cholinesterase inhibitors for Parkinson’s disease-related visual hallucinations unresponsive to atypical antipsychotics

Archives of Medical Science, 2007
Introduction: Considering lack of accepted guideline in cases of Parkinson’s disease-related visual hallucinations with poor response or intolerance to antipsychotics, and their possible cholinergic pathogenesis, the trial with cholinesterase inhibitors ...
Tomasz Sobow
doaj  

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, Volume 183, Issue 13, Page 3762-3779, July 2026.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source