Results 91 to 100 of about 25,099 (263)

Study of cholinesterase inhibitors

, 2014
Tato diplomová práce se zabývala studiem enzymů a jejich inhibitorů. Cholinesterázy patří mezi specializované karboxylové hydrolázy, které katalyzují hydrolýzu esterů cholinu.
Sejpková, Tereza
core  

Evolución del consumo de fármacos específicos para la demencia en la comunidad autónoma de Madrid durante el periodo 2002-2012

Neurología, 2015
Resumen: Introducción: El análisis del consumo de fármacos en grandes grupos poblacionales permite ver tendencias de consumo y comparar diferentes ámbitos.
M.C. de Hoyos-Alonso, E. Tapias-Merino, C.M. Meseguer Barros, M. Sánchez-Martínez, A. Otero   +4 more
doaj   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

, 2005
Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 - December 2004), PsychINFO (1972 December 2004), EMBASE (1980 - December 2004), CINHAL (1982 ...
Boustani, Malaz, Boustani, M., Fox, C., Maidment, Ian D., Fox, Christopher, Maidment, I. D.   +5 more
core   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real‐World Data Screening and in Vitro Validation

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Drug repositioning analysis identifies candidate therapeutic agents for Alzheimer’s diseaseand supports further mechanistic and translational investigation. ABSTRACT Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval.
Sho Sakagami, Yuya Yoshida, Shota Uemura, Taisei Kumamoto, Ryotaro Tsukamoto, Takumi Nishi, Shimpei Kawano, Kohei Fukuoka, Hanami Ino, Kengo Hamamura, Shigehiro Ohdo, Naoya Matsunaga   +11 more
wiley   +1 more source

Outcome‐specific risk factors challenge universal dementia prevention priorities: Findings from the Egyptian Dementia Network Registry

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Graphical Abstract illustrating how the different risk factors relate to dementia diagnosis and cognitive performance. Solid arrows indicate robust associations in this cohort; dashed arrows indicate weaker or imprecise associations. Abstract BACKGROUND Dementia prevention targets modifiable factors from high‐income cohorts, but most studies conflate ...
Shimaa A. Heikal, Eman M. Khedr, Gharib Fawi, Mai Othman, Nesma G. Elsheikh, Heba M. Tawfik, Hany I. Hassanin, Sara ElFarrash, Samer Salama, Eman M. Ali, Amna Ibrahim, Ahmed Qayaty, Sara A. Moustafa, Mohamed Salama   +13 more
wiley   +1 more source

Provider and patient perspectives on the diagnosis and treatment of Alzheimer's disease: A global perspective from the Global Alzheimer's Leadership Series (GoALS)

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world‐leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care.
Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R Jack Jr, Gregory A Jicha, Simin Mahinrad, Eric McDade, Catherine J Mummery, Ronald C Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. van der Flier, Bruno Vellas, David Wallon, Jeff D Williamson, Donna Wilcock, Maria C. Carrillo   +26 more
wiley   +1 more source

Dual-mode cholinesterase inhibitors targeting muscarinic receptors [PDF]

, 2007
A gallamine-tacrine dimer and related analogues are presented. These compounds act as dual-mode cholinesterase inhibitors and additionally as allosteric modulators of muscarinic M2 receptors.
Elsinghorst, Paul Wilhelm
core  

Interactions between oxotremorine and inhibitors of Cholinesterase enzymes

, 1973
Interactions between oxotremorine and physostigmine or dyflos have been investigated in mice using doses giving approximately 50% inhibition of mouse brain cholinesterase.
S J Tha, B Cox
core   +1 more source

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +1 more source