Results 111 to 120 of about 25,099 (263)

Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus–Dentate Gyrus Circuit

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Electroacupuncture at ST36 alleviates cognitive deficits and restores hippocampal synaptic plasticity in VCI rats by activating the SuMGlu‐DG circuit. This study identifies the SuMGlu‐DG circuit as an essential mediator for the therapeutic and neuroprotective effects of acupuncture in vascular‐induced cognitive decline.
Fang Wan, Lu Wang, Qing‐Yong Wang, Jing‐Wen Yang, Cun‐Zhi Liu   +4 more
wiley   +1 more source

Nanoparticles in Vascular Dementia: Advantages and Challenges

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu, JiaLi Hu, Yueming qiu, Huaying Wang, Chunxiao Shen, Ziying Liu, Yiting He, Xuefei Du, Xiaorong Zhang   +8 more
wiley   +1 more source

Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease

, 2008
Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease (AD) indicate that the short and long term actions of ChEIs are dissimilar. fMRI studies of the ChEI rivastigmine have focused on its short term action.
Shanks, Michael F, Venneri, Annalena, McGeown, William J, Annalena Venneri   +3 more
core   +1 more source

Lecanemab Reduces Neuropsychiatric Symptoms and Related Regional Brain Amyloid Load in Early Alzheimer's Disease: A Preliminary Prospective Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This prospective study shows that 6 months of lecanemab treatment significantly reduces brain amyloid load and improves neuropsychiatric symptoms in early Alzheimer's disease. These improvements are linked to amyloid clearance and structural changes in emotion‐related brain regions, indicating benefits beyond cognition.
Yan Chang, Hua Li, Xiaojie Liu, Xuemei Li, Jiajin Liu, Jingbin Song, Huaping Fu, Xiaodan Xu, Yuan Wang, Qianyao Wang, Na Ren, Jilin Chen, Xin Deng, Xue Zhang, Luofei Zuo, Bo Zhou, Xuan Sun, Zihan Li, Yuanyan Cao, Runze Wu, Jianjun Jia, Hairong Qian, Ruimin Wang   +22 more
wiley   +1 more source

Wearable biofluids colorimetric biosensors

FlexMat, Volume 3, Issue 2, Page 299-326, June 2026.
Wearable and flexible colorimetric sensors enable real‐time, non‐invasive detection through visible color changes. Advances in materials and device engineering have driven their development; however, challenges remain in sensitivity, selectivity, and scalable manufacturing.
Zhaoyuan Lyu, Zhiqiang Xiao, Wenhao Shen, Cheng Liu, Te Gu, Ruchuan Cao, Fangyu Zhang, Chuizhou Meng, Shichao Ding   +8 more
wiley   +1 more source

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

, 2018
Kamil Kuca,1,2 Jana Zdarova Karasova,2,3 Ondrej Soukup,2 Jiri Kassa,3 Eva Novotna,2 Vendula Sepsova,2,3 Anna Horova,2 Jaroslav Pejchal,3 Martina Hrabinova,2,3 Eva Vodakova,2 Daniel Jun,2,3 Eugenie Nepovimova,1,2 Martin Valis,4 Kamil Musilek1,2 ...
Karasova JZ, Musilek K, Kuca K, Novotna E, Hrabinova M, Soukup O, Sepsova V, Pejchal J, Jun D, Nepovimova E, Horova A, Kassa J, Vodakova E, Valis M   +13 more
core  

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

cholinesterase inhibitor

Citation: 'cholinesterase inhibitor' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15556 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source