Results 131 to 140 of about 25,099 (263)

Theta burst stimulation for depressive symptoms in early‐stage dementia with Lewy bodies: Protocol for a single‐arm open‐label feasibility study (DL‐TBS Study)

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Depressive symptoms are highly prevalent in early‐stage dementia with Lewy bodies (DLB) and are associated with impaired quality of life, functional decline, and increased caregiver burden. However, effective and well‐tolerated treatment options for depression in this population remain limited because of marked drug sensitivity and ...
Shun Takahashi, Yuto Satake, Masahiro Hata, Hisaki Omori, Koichi Hosomi, Manabu Ikeda   +5 more
wiley   +1 more source

Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li, Manying Yang, Jiale Tao, Yonghong Zhao, Na Zhao, Shiguo Sun   +5 more
wiley   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Quantifying Population Reversibility of Sensor Performance in Multi‐Cycle Single‐Sensor Recovery Assay

Small, Volume 22, Issue 33, 12 June 2026.
Single‐walled carbon nanotubes (SWCNTs) are versatile optical nanosensors that can be imaged at the single‐sensor level to map biological processes. To translate such imaging into calibrated measurements, sensor recovery under repeated analyte exposures must be analyzed.
Geffen Rosenberg, Gili Bisker
wiley   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur, Mustafa Çeşme, Ferhan Tümer   +2 more
wiley   +1 more source

The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross‐Sectional Study

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Total flavonoid intake was significantly inversely associated with neurodegenerative diseases risk. Participants in the highest quartile (Q4) of total flavonoid intake exhibited a 48% lower risk compared to those in the lowest quartile (Q1) (OR = 0.52, 95% CI: 0.31–0.90; p for trend = 0.016).
Chenzhong Zong, Yang Dong, Xue Yu, Yu He, Xiaoqing Zhang, Kuo Gao   +5 more
wiley   +1 more source

Evaluation of Dialkyl Aryl Phosphates as Selective Inhibitors of Butyryl Cholinesterase

, 2016
Evaluation of Dialkyl Aryl Phosphates as Selective Inhibitors of Butyryl Cholinesterase Analisa Garcia Biochemistry 2016 ...
Garcia, Analisa
core  

Association of Mitral Annular Disjunction on Magnetic Resonance Imaging With Cardiovascular Outcomes

European Journal of Clinical Investigation, Volume 56, Issue 6, June 2026.
In 1969, consecutive patients undergoing CMR, MAD was assessed in end‐diastole and end‐systole across 2‐, 3‐, and 4‐chamber views (panels A–F, lower left), and native T1 relaxation times were measured at the mitral annulus (upper left, T1 colour map).
Katharina Mascherbauer, Nikolai Nantschev, Christina Kronberger, Carolina Donà, Matthias Koschutnik, Varius Dannenberg, Michael Poledniczek, Lena Schmid, Katharina Singer, Laura Lunzer, Sophia Koschatko, Charlotte Jantsch, Gregor Heitzinger, Kseniya Halavina, Christian Nitsche, Franz Duca, Dietrich Beitzke, Christian Loewe, Philipp Bartko, Julia Mascherbauer, Christian Hengstenberg, Andreas Kammerlander   +21 more
wiley   +1 more source

The efficacy of adjuvant therapies in combination with cholinesterase inhibitors for the treatment of Alzheimer\u27s disease

, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that presents primarily in the elderly with short-term memory loss, cognitive decline and loss of functional ability.
Bohus, Kaitlyn
core