Results 141 to 150 of about 25,099 (263)

Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism [PDF]

, 2019
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tereza Kalinová Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Mentor: Assoc. Prof. Jana Hroudová, Pharm.D., Ph.D.
Kalinová, Tereza
core  

Cholinesterase inhibitors for patients with dementia: Patterns of prescribing and disparities in treatment. [PDF]

J Alzheimers Dis
Heo RJ, Negida A, Barrett MJ, Chrenka EA, Bayram E, Kane JPM, Werner AM, Rossom RC, Wyman-Chick KA.   +8 more
europepmc   +2 more sources

Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Freezing of gait (FoG) occurs across Parkinson's disease, multiple neurodegenerative conditions and non‐neurodegenerative disorders. This review synthesizes the structural, neurochemical and proteinopathic substrates underlying FoG, showing how cumulative damage to distributed locomotor circuits—compounded by overlapping pathologies—progressively ...
Gabor G. Kovacs
wiley   +1 more source

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1687-1691, June 2026.
ABSTRACT Background Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long‐term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older.
Ophir Lavon, Wafaa Hamodi, Sameer Kassem
wiley   +1 more source

Association of Combined Lifestyle Behaviors With Healthspan in Older Adults

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1614-1625, June 2026.
In 11,287 older adults from the ASPirin in Reducing Events in the Elderly (ASPREE) cohort, healthy lifestyle behaviors were defined as Mediterranean diet, regular physical activity, moderate alcohol intake, and non‐smoking. Participants with three or more favorable behaviors had a 40% lower hazard of death, dementia, or persistent physical disability ...
Catherine Robb, Prudence R. Carr, Jocasta Ball, Galina Polekhina, Daniel Clayton‐Chubb, Elena S. George, Jessica Fitzpatrick, Lawrence J. Beilin, Anne B. Newman, Alice Owen, Suzanne G. Orchard, Cammie Tran, Joanne Ryan, John J. McNeil   +13 more
wiley   +1 more source

The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1658-1667, June 2026.
ABSTRACT Background Hip fractures are a significant public health concern, associated with substantial morbidity and mortality. Mortality is the most serious consequence of hip fractures, with a 1‐year rate ranging from 14% to 36%. Hospital harms are also more prevalent among older adults with hip fractures, further increasing their risk of mortality ...
Anum Ali, Arrani Senthinathan, Laleh Rashidian, Yu Qing Bai, Walter P. Wodchis, Susan E. Bronskill, Chantal Backman, Kednapa Thavorn, Kerry Kuluski, Sara J. T. Guilcher   +9 more
wiley   +1 more source

Sensory Impairment and Risk of Elder Mistreatment in Community‐Dwelling Older Adults

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1668-1675, June 2026.
Adjusted probabilities of elder mistreatment based on none, one, or multi‐sensory impairments (vision, hearing, and/or olfaction). Results suggest an association between multisensory loss and elder mistreatment risk. ABSTRACT Background Emotional and financial mistreatment among older adults is often under‐recognized among clinicians. Exploring whether
Mara W Rosenberg, Evelyn Li, Wei‐Lin Xue, Elizabeth Eckstrom, Melissa Howe, Alexander K. Smith, Ashwin A. Kotwal   +6 more
wiley   +1 more source

Designing Consent Processes for Research With Older Adults Who May Lack Decisional Capacity: A Guide for Investigators

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1715-1721, June 2026.
ABSTRACT Securing a participant's voluntary, informed consent is widely acknowledged as a requirement of ethical research. Yet, challenges can arise, particularly when a researcher seeks to enroll older adults who may lack the capacity to consent to research participation due to cognitive impairment.
Emily A. Largent, Stephanie R. Morain, Jason Karlawish   +2 more
wiley   +1 more source

Clinical Diabetic Peripheral Neuropathy: Can It Be Reversed? Arguments for and Against From a NEUROdiab Debate

Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Diabetic peripheral neuropathy (DPN) is a prevalent and disabling complication of diabetes, yet whether established clinical DPN is reversible remains debated. At the 35th Annual Meeting of NEUROdiab, a formal debate examined arguments ‘for’ and ‘against’ the proposition that clinical DPN can be reversed.
Gordon Sloan, Shazli Azmi, Stephanie Eid, Maryam Ferdousi, Johan Røikjer, Zoltan Kender, Luca D'Onofrio, Eleni Karlafti, Brian Callaghan, Bruce A. Perkins   +9 more
wiley   +1 more source

New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation. [PDF]

Sci Rep
Omar MA, Al-Ashmawy AAK, Abd El Salam HA, El-Shiekh RA, Aboulthana WM, Srour AM.   +5 more
europepmc   +1 more source