Results 121 to 130 of about 25,099 (263)

An Overview on Natural Cholinesterase Inhibitors - A Multi-Targeted Drug Class - and Their Mass Production

, 2011
Cholinesterase enzyme family consisting of acetylcholinesterase (AChE) and butrylcholinesterase (BChE) is important in pathogenesis of Alzheimer's disease (AD), explained by "cholinergic hypothesis".
G. Orhan, Gurkas, E., I. Erdogan Orhan, Orhan, G., Orhan, İLKAY, E. Gurkas   +5 more
core   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism [PDF]

, 2020
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tereza Kalinová Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Mentor: Assoc. Prof. Jana Hroudová, Pharm.D., Ph.D.
Nowak, Tereza
core  

Ocular surface alterations in agricultural workers exposed to pesticides in Cundinamarca, Colombia

JFO Open Ophthalmology
Background: The cholinergic system regulates a variety of structures on the ocular surface and maintains homeostasis. Therefore, dysregulation of cholinergic activity could impact lacrimal and conjunctival function.
Yuly-N. Franco, Lina-F. Gama, Alejandro León-Álvarez, Martín-E. Giraldo, J.-Cesar Montañez, Sandra-C. Durán-Cristiano   +5 more
doaj   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source

Cardiac effects of cholinesterase inhibitors:a reason for restraint?

, 2009
Cholinesterase inhibitors are prescribed in the treatment of mild to moderate Alzheimer's dementia. Little is known about the cardiac safety of these drugs.
Boomkamp-Snoeren, C M, van Puijenbroek, E; id_orcid, van Puijenbroek, E, van Marum, R J, Salarbaks, A M, Jansen, P A F   +5 more
core   +2 more sources

Two cases of Alzheimer's disease showing deterioration of behavioral and psychological symptoms of dementia induced by switching from rivastigmine to donepezil

Neuropsychiatric Disease and Treatment, 2012
Takemi Kimura, Junichi TakamatsuDivision of Clinical Research, National Hospital Organization Kikuchi Hospital, Koshi, Kumamoto, JapanAbstract: Rivastigmine, galantamine, and memantine, in addition to donepezil, which has been on the market over 10 years,
Kimura T, Takamatsu J
doaj  

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

The importance of longitudinal evaluation using DAT‐SPECT in organophosphate‐induced toxic parkinsonism

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao, Yoichiro Kogoh, Hideki Funahashi, Yusei Yanoma, Minako Azuma, Yasushi Ishida, Yoji Hirano   +6 more
wiley   +1 more source

Patterns of use and adverse events associated with cholinesterase inhibitors in older adults with dementia

, 2004
Cholinesterase inhibitors have been widely adopted to manage the symptoms of Alzheimer's disease and related dementias. Cholinesterase inhibitors can precipitate urinary incontinence, but this adverse drug effect may go undetected because incontinence is
Gill, Sudeep Singh
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