Results 121 to 130 of about 129,913 (308)
Advanced Science, EarlyView.Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce +8 more
wiley +1 more source
BiomedicinesBackground/Objectives: Previously, we reported that high molecular weight hyaluronic acid (HMW-HA) exerts chondroprotective effects by enhancing dual specificity protein phosphatase 10/mitogen-activated protein kinase (MAPK) phosphatase 5 (DUSP10/MKP5 ...
Wataru Ariyoshi +5 more
doaj +1 more source
Advanced Science, EarlyView.Through the actuation of cell contractile forces, geometrically complex structures are formed via a bioprinted, rapidly degrading cell‐laden hydrogel system, resulting in cell‐only condensation within a few days of culture. This system supports stem cell differentiation down different lineages and new tissue formation, such as chondrogenesis and ...
Aixiang Ding +4 more
wiley +1 more source
Advanced Science, EarlyView.Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen +14 more
wiley +1 more source
Bioregulation of lubricin expression by growth factors and cytokines [PDF]
European Cells & Materials, 2007 Lubricin, also commonly referred to as superficial zone protein (SZP) and proteoglycan 4 (PRG4), is a multifaceted, cytoprotective glycoprotein that contributes to the boundary lubrication properties facilitating low friction levels at interfacing ...
A R C Jones, C R Flannery
doaj
Multiscale mechanics of tissue‐engineered cartilage grown from human chondrocytes and human‐induced pluripotent stem cells [PDF]
, 2020 Jill M. Middendorf +6 more
openalex +1 more source
Advanced Science, EarlyView.A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying +6 more
wiley +1 more source
Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes [PDF]
, 2020 Mitsuhiro Hoshijima +6 more
openalex +1 more source
Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes [PDF]
, 2021 Annett Eitner +7 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source