Results 121 to 130 of about 170,603 (392)
Cartilage on the Move: Cartilage Lineage Tracing During Tadpole Metamorphosis
, 2012 The reorganization of cranial cartilages during tadpole metamorphosis is a set of complex processes. The fates of larval cartilage-forming cells (chondrocytes) and sources of adult chondrocytes are largely unknown.
Brittain, Alison L. +3 more
core +1 more source
The role of the chondrocyte in osteoarthritis [PDF]
Arthritis & Rheumatism, 2000 Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage or to sites of trauma, repetitive mechanical injury has been proposed as the critical signal for the initiation and progression of OA. It is now generally accepted that
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex +4 more
wiley +1 more source
Cell Calcification Models and Their Implications for Medicine and Biomaterial Research
Advanced Healthcare Materials, EarlyView.Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley +1 more source
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Nature Communications, 2016 Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage.
Yasuhito Yahara +14 more
semanticscholar +1 more source
At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis
Advanced Healthcare Materials, EarlyView.Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang +5 more
wiley +1 more source
A single-cell 3D dynamic volume control system for chondrocytes
BioTechniquesIn articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang +5 more
doaj +1 more source
Biology Open, 2015 According to the general understanding, the chondrocyte lineage terminates with the elimination of late hypertrophic cells by apoptosis in the growth plate.
Jung Park +10 more
semanticscholar +1 more source
Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]
, 2015 Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi +3 more
core +1 more source