Results 121 to 130 of about 131,500 (355)

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

Journal of Orthopaedic Translation, 2020
Xudong Yao, Kai Sun, Shengnan Yu, Jia-hui Luo, Jiachao Guo, Jiamin Lin, Genchun Wang, Zhou Guo, Yaping Ye, Fengjing Guo   +9 more
semanticscholar   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

From Chondrocytes to Chondrons, Maintenance of Phenotype and Matrix Production in a Composite 3D Hydrogel Scaffold [PDF]

, 2022
Mahmoud Amr, Alia Mallah, Samina Yasmeen, Bernard Van Wie, B. Arda Gozen, Juana Mendenhall, Nehal I. Abu‐Lail   +6 more
openalex   +1 more source

Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy

Advanced Science, EarlyView.
A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen, Yanguo Su, Guiyuan Zhao, Jiaojiao Tao, Qijie Diao, Guangli Xiang, Tianze Jiang, Lu Han, Xia Zhao   +8 more
wiley   +1 more source

Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway

Bone & Joint Research
Aims: Osteoarthritis (OA) is the most common chronic pathema of human joints. The pathogenesis is complex, involving physiological and mechanical factors. In previous studies, we found that ferroptosis is intimately related to OA, while the role of Sat1
Jingting Xu, Zhaoxuan Ruan, Zhou Guo, Liangcai Hou, Genchun Wang, Zehang Zheng, Xiong Zhang, Haigang Liu, Kai Sun, Fengjing Guo   +9 more
doaj   +1 more source

Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds [PDF]

, 2019
Manabu Kawata, Daisuke Mori, Kosuke Kanke, Hironori Hojo, Shinsuke Ohba, Ung‐il Chung, Fumiko Yano, Hideki Masaki, Makoto Otsu, Hiromitsu Nakauchi, Sakae Tanaka, Taku Saito   +11 more
openalex   +1 more source

Synovial Fluid Regulates the Gene Expression of a Pattern of microRNA via the NF-κB Pathway: An In Vitro Study on Human Osteoarthritic Chondrocytes [PDF]

, 2022
Sara Cheleschi, Sara Tenti, Sauro Lorenzini, Iole Seccafico, Stefano Barbagli, Elena Frati, Antonella Fioravanti   +6 more
openalex   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

The transcriptional cofactor Jab1/Cops5 is crucial for BMP‐mediated mouse chondrocyte differentiation by repressing p53 activity

, 2021
Murali K. Mamidi, William E. Samsa, Lindsay A. Bashur, Yuqing Chen, Ricky Chan, Brendan Lee, Guang Zhou   +6 more
openalex   +2 more sources

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source