Results 131 to 140 of about 156,620 (407)

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis [PDF]

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression.
arxiv   +1 more source

Modeling the Effect of Blunt Impact on Mitochondrial Dysfunction in Cartilage [PDF]

, 2016
Mounting evidence for the role of oxidative stress in the degeneration of articular cartilage after an injurious impact requires our modeling & simulation efforts to temporarily shift from just describing the effect of mechanical stress and inflammation on osteoarthritis (OA).
arxiv   +1 more source

Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint [PDF]

, 2017
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury.
Chinzei, Nobuaki, Duan, Xin, Holguin, Nilsson, Quirk, James D, Rai, Muhammad Farooq, Sandell, Linda J, Schmidt, Eric J, Silva, Matthew J   +7 more
core   +3 more sources

Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling

Brazilian Journal of Medical and Biological Research
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression.
Wang Han, Mengtong Guan, Bo Liao, Xiaoyu Han, Kaiting Li, Qing Chen, Xiya Guo, Yajuan Niu, Ying Zhu, Dingqun Bai   +9 more
doaj   +1 more source

Ultra‐Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling

Advanced Materials, EarlyView.
3D bioprinting merges tissue engineering and additive manufacturing to create biological structures. A bioink is developed by modifying hyaluronic acid, a natural extracellular matrix polymer, with cysteine. Potassium iodide is later added to tune gelation kinetics, enabling fine printing with a 32G needle.
Shima Tavakoli, Aybike Kocatürkmen, Oommen P. Oommen, Oommen P. Varghese   +3 more
wiley   +1 more source

Applications of Chondrocyte-Based Cartilage Engineering: An Overview

BioMed Research International, 2016
Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs ...
A. Phull, Seong-Hui Eo, Q. Abbas, Madiha Ahmed, Song-Ja Kim   +4 more
semanticscholar   +1 more source

Adipochondrocytes in rabbit auricular cartilage [PDF]

arXiv, 2018
Chondrocytes are described as one cell population in different cartilage types. The auricular cartilage in mouse and rat contains unique chondrocytes similar in morphology to white adipocytes and known as lipochondrocytes. Lipochondrocytes were not mentioned in other species. The current study aimed to explore the existence of this cell type in rabbits.
arxiv  

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes [PDF]

, 2015
Zhao Wang is funded on a China Scholarships PhD Studentship. Jerome Irianto was supported on a project grant from The Wellcome Trust (ref no. 084717)
Baaijens, Bader, Borghetti, Bush, Bush, Bush, Bush, Cantiello, Chalut, Chao, Chen, Dahl, Darling, Erickson, Fletcher, Guilak, Guilak, Guilak, Hopewell, Huttu, Irianto, J. Irianto, Jones, Kerrigan, Kerrigan, Kerrigan, Knight, Knight, Koay, Korhonen, Leipzig, Li, Lohr, M.M. Knight, McArthur, Mobasheri, Moran, Ohashi, Okada, Okumura, Ordaz, Pajerowski, Phan, Pravincumar, Pritchard, Quist, Qusous, Qusous, S. Kazun, Sato, Souza, Stewart, Theret, Trickey, Trickey, Turunen, Urban, Urban, Van Inwegen, Voets, W. Wang, Z. Wang   +61 more
core   +1 more source

Bioxolography Using Diphenyliodonium Chloride and N‐Vinylpyrrolidone Enables Rapid High‐Resolution Volumetric 3D Printing of Spatially Encoded Living Matter

Advanced Materials, EarlyView.
Bioxolography, a novel volumetric 3D‐bioprinting technique, enables rapid and high‐resolution fabrication of >1 cm3 engineered living materials. A newly developed three‐component photoinitiator system significantly enhances the photoreactivity of gelatin methacryloyl‐based bioresins, allowing for precise xolographic bioprinting.
Alexis Wolfel, Castro Johnbosco, Annalise Anspach, Marieke Meteling, Jos Olijve, Niklas Felix König, Jeroen Leijten   +6 more
wiley   +1 more source

Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis.

Journal of Clinical Investigation, 2016
Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death precedes cartilage damage, but how the loss of chondrocytes affects cartilage integrity is not
Minjie Zhang, Sriniwasan B. Mani, Y. He, A. Hall, Lin Xu, Yefu Li, D. Zurakowski, G. Jay, M. Warman   +8 more
semanticscholar   +1 more source