Results 211 to 220 of about 118,065 (344)

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritis. [PDF]

EBioMedicine
Tian W, Dong SS, Jiang F, Zhang JQ, Wang C, He CY, Hu SY, Hao RH, Song HM, Gao HW, An K, Zhu DL, Yang Z, Guo Y, Yang TL.   +14 more
europepmc   +1 more source

MODULATION DE L'EXPRESSION DE GENES DE COLLAGENE DANS DES CHONDROCYTES EPIPHYSAIRES DE LAPIN EN CULTURE [PDF]

, 1989
V. Nataf, L. Tsagris, Jacky Bonaventure, MT Corvol   +3 more
openalex   +1 more source

Monocyte‐derived macrophages‐synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3. [PDF]

Sci Adv
Deng C, Yu L, Zhao X, Chen Y, Mei J, Wei J, Chen X, Lei G, Zeng C.   +8 more
europepmc   +1 more source

Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu, Thais de las Heras Ruiz, Francesca M. Johnson de Sousa Brito, Jamie Soul, Jonathan Coxhead, Matthew J. German, David A. Young, Ana M. Ferreira‐Duarte, Katarzyna A. Piróg   +8 more
wiley   +1 more source

Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway. [PDF]

J Orthop Surg Res
Ozbek H, Yilmaz I, Akyuz A, Pehlivanoglu S, Sirin DY, Albayrak M, Yilmaz OF.   +6 more
europepmc   +1 more source

3D Culture in Functionalized FN‐Silk Networks Facilitate Proliferation, Differentiation and Phenotypic Stability of Mature Human Primary Cells and Stem Cells

Biotechnology and Bioengineering, EarlyView.
The authors present a new technique for 3D culture of mammalian cells with the support of a microfiber‐based network of fibronectin (FN)‐functionalized recombinant silk. This feasible 2‐step method results in highly viable free‐floating 3D cultures with tissue‐mimicking morphology.
Astrid Källén, Nayere Taebnia, Mona Widhe, Volker M. Lauschke, My Hedhammar   +4 more
wiley   +1 more source

Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy. [PDF]

J Nanobiotechnology
He X, Liu X, Cheng X, Zhu C, Chen Y, Wang Y, Zhou Y, Shen H, Yang H, Xu Y, Shi Q, Niu J.   +11 more
europepmc   +1 more source

Scalable, High‐Density Expansion of Human Mesenchymal Stem Cells on Microcarriers Using the Bach Impeller in Stirred‐Tank Reactors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT This paper describes the results of process developmental experiments to achieve higher cell densities in the manufacturing of hMSCs using the novel Bach impeller in a stirred‐tank bioreactor. Engineering experiments have previously shown that the Bach impeller represents an efficient mixing device that suspends particles in fluids at low ...
Tom A. Wyrobnik, Laia Miranda, Alan Lam, Steve Oh, Andrea Ducci, Martina Micheletti   +5 more
wiley   +1 more source