Results 191 to 200 of about 70,223 (315)

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu   +5 more
wiley   +1 more source

Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis. [PDF]

Cell Commun Signal
Mei J, Wei P, Schäfer N, Ehrnsperger M, Johnstone B, Matalova E, Grässel S.   +6 more
europepmc   +1 more source

Surgical caseload and annual volume influence cartilage treatment strategies in primary anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate how surgeon and clinic volume, along with patient‐, injury‐ and surgery‐related factors, influence cartilage injury management in primary anterior cruciate ligament reconstruction (ACLR). Methods This retrospective cohort study analysed cartilage treatment (debridement, microfracture, other methods or left in situ) in ...
Dzan Rizvanovic, Markus Waldén, Magnus Forssblad, Anders Stålman   +3 more
wiley   +1 more source

Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology. [PDF]

Mol Ther
Posey KL, Coustry F, Veerisetty AC, Hossain M, Gattis D, Booten S, Alcorn JL, Seth PP, Hecht JT.   +8 more
europepmc   +1 more source

Microfracture for full‐thickness chondral lesions of the knee in elite athletes leads to high return‐to‐play rates

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Injuries to the knee are common in elite athletes and often involve damage to the articular cartilage. Given the high demands of elite sport, full‐thickness articular cartilage defects in the knee can be career‐limiting or threatening.
David J. Haslhofer, Jobe Shatrov, Mary Jones, Wahid Abdul, Arman Motesharei, Simon V. Ball, Andy Williams   +6 more
wiley   +1 more source

Recombinant Spider Silk Enhances Engineered Cartilage Formation. [PDF]

J Funct Biomater
Zhang H, Huang X, Zhang J, Zhang F, Sun F, Wan C.   +5 more
europepmc   +1 more source

MOCART 2.0 score of 60 or greater measured at 1 year post‐operatively predicts favourable clinical outcomes after surgical repair of tibiofemoral cartilage lesions

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose (1) To evaluate the relationship between the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2.0 score and post‐operative clinical outcomes following surgical repair of cartilage lesions in the tibiofemoral joint, and (2) to determine threshold values of the 1‐year MOCART 2.0 score associated with favourable patient ...
Hyun‐Soo Moon, Sungjun Kim, Chong‐Hyuk Choi, Min Jung, Kwangho Chung, Se‐Han Jung, Jin‐Gyu Kim, Min‐Cheol Park, Sung‐Hwan Kim   +8 more
wiley   +1 more source

Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization. [PDF]

Bone Res
Li C, Xu Y, Zhou L, Chang L, Dan Z, Jiang Y, Wang C, Deng L, Tang G.   +8 more
europepmc   +1 more source

Spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting restores physiological cartilage and subchondral bone properties in osteochondral knee defects ‐ An MRI‐based analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study aimed to evaluate the radiological and patient‐reported outcome measures (PROMs) following spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for the treatment of osteochondral defects of the knee.
Stephan Oehme, Benjamin Bartek, Janne Callsen, Jessica Schallock, Tobias Winkler, Thorsten Diekhoff, Tobias Jung, Danko Dan Milinkovic   +7 more
wiley   +1 more source

ADORA2B, deubiquitinated by USP14, facilitates IL-1β-induced chondrocyte apoptosis, ferroptosis and inflammation to accelerate osteoarthritis process. [PDF]

Medicine (Baltimore)
Li Z, Zhang P, Ouyang C, Shen Z, Guo G.
europepmc   +1 more source