Results 171 to 180 of about 97,625 (307)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Exosomes: critical mediator and therapeutic target for osteoarthritis. [PDF]

Am J Transl Res
Jiang P, Liu J, Li H, Shao H, Tan H, Liu F, Ling P, Han Q, Dou X.   +8 more
europepmc   +1 more source

Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain

Interdisciplinary Medicine, EarlyView.
A fully characterised organ‐on‐a‐chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successfully recapitulates the physiological effects of pulsatile vessel dilation on cell morphology and the localised inflammatory susceptibility to TNF‐α ...
Yu Hou, Georgios Ziakas, Tim Hopkins, Wen Wang, Hazel R. C. Screen, Martin M. Knight   +5 more
wiley   +1 more source

Revisiting the Chondrotoxicity of Intra-Articular Triamcinolone Acetonide in Osteoarthritis: Dose Dependence and Experimental Model Heterogeneity [Letter]. [PDF]

J Pain Res
Liu Q, Du H.
europepmc   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review. [PDF]

J Cell Mol Med
Yi Q, Li J, Luo G, Li J, Yang D, Sun W, Sun W, You W, Yang L.   +8 more
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu   +5 more
wiley   +1 more source

cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis. [PDF]

Cell Death Dis
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y.
europepmc   +1 more source

Surgical caseload and annual volume influence cartilage treatment strategies in primary anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate how surgeon and clinic volume, along with patient‐, injury‐ and surgery‐related factors, influence cartilage injury management in primary anterior cruciate ligament reconstruction (ACLR). Methods This retrospective cohort study analysed cartilage treatment (debridement, microfracture, other methods or left in situ) in ...
Dzan Rizvanovic, Markus Waldén, Magnus Forssblad, Anders Stålman   +3 more
wiley   +1 more source