Results 291 to 300 of about 131,500 (355)
Some of the next articles are maybe not open access.

Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes

ACS Nano, 2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (
Xiaolin Cui, Tun Yuan, Yujiang Fan
exaly   +2 more sources

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

ACS Applied Materials & Interfaces, 2020
Targeted delivery to the diseased cell or tissue is the key to the successful clinical use of nucleic acid drugs. In particular, delivery of microRNA-140 (miRNA-140, miR-140) into chondrocytes across the dense, nonvascular extracellular matrix of ...
Yujie Liang, Xiao Xu, Jianyi Xiong
exaly   +2 more sources

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

Annals of the Rheumatic Diseases, 2022
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression.
Haiyan Zhang   +13 more
semanticscholar   +1 more source

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

open access: yesInternational Journal of Molecular Sciences, 2015
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA),
Hyun Ah Kim
exaly   +2 more sources

The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification

open access: yesBone Research, 2018
There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures.
Patrick Aghajanian, Subburaman Mohan
exaly   +2 more sources

The chondrocyte

The International Journal of Biochemistry & Cell Biology, 2003
The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement.
Archer, C W, Francis-West, P
openaire   +3 more sources

Chondrocyte transplantation

Arthroscopy: The Journal of Arthroscopic & Related Surgery, 1996
The transplantation of chondrocytes as a treatment to repair defects and degeneration in hyaline articular cartilage is being tested in numerous laboratory and clinical settings. This has included transplanting chondrocytes grown in tissue culture that were procured from non-weight-bearing areas of the affected joint to transplanting allografts with ...
D W, Jackson, T M, Simon
openaire   +2 more sources

SOX9 and the many facets of its regulation in the chondrocyte lineage

open access: yesConnective Tissue Research, 2017
Véronique Lefebvre, Mona Dvir-Ginzberg
exaly   +2 more sources

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