Results 321 to 330 of about 170,603 (392)

siRNAs, tRNAs, and rRNAs in Osteoarthritis: Biological Functions and Therapeutic Opportunities. [PDF]

Biologics
Wang M, Dai Y, Ge X, Zheng L, Zhai M, Li W, Liu G, Cheng X, Wei J, Yang X, Liu L, Liu H, Sun J, Li B, Yuan F.   +14 more
europepmc   +1 more source

Spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting restores physiological cartilage and subchondral bone properties in osteochondral knee defects ‐ An MRI‐based analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study aimed to evaluate the radiological and patient‐reported outcome measures (PROMs) following spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for the treatment of osteochondral defects of the knee.
Stephan Oehme, Benjamin Bartek, Janne Callsen, Jessica Schallock, Tobias Winkler, Thorsten Diekhoff, Tobias Jung, Danko Dan Milinkovic   +7 more
wiley   +1 more source

Therapeutic Window of Laser Dosimetry for the Treatment of Knee Osteoarthritis

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives We propose a non‐destructive laser method that uses controlled thermomechanical action to treat degenerative cartilage changes. The technique aims to reduce pain, offers a minimally invasive option for early‐ to mid‐stage degeneration, and lessens the need for joint replacement.
Yulia Alexandrovskaya, Felix Feldchtein, Andreas Glatz, Anatoly Shekhter, Elizaveta Kon, Valerii Vinokur, Emil Sobol   +6 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis by Suppressing NLRP3-Mediated Synovial Inflammation in the Early Stages of the Disease. [PDF]

Stem Cells Int
Li Y, Ouyang Y, Lang R, He J, Zheng S, Ao C, Jiang Y, Xiao H, Li M, Li C, Wu D.   +10 more
europepmc   +1 more source

A Biofunctional Hydrogel/Nanofiber Bilayer Scaffold Delivering EGF and TGFβ3 for Advanced Nasal Tissue Reconstruction

Macromolecular Materials and Engineering, EarlyView.
This study develops a biomimetic bilayer scaffold based on gelatin methacryloyl‐ciprofloxacin/polycaprolactone‐collagen (GelMA‐CIP/PCL‐COL), designed to release EGF and TGFβ3 in a controlled manner. The GelMA‐CIP@PVA‐EGF/PCL‐COL@PVA‐TGFβ3 scaffold currently demonstrates sustained delivery of growth factors for 28 days, mechanical properties similar to ...
Hilal Yilmaz, Sevda Gursoy, Gulsah Torkay, Shhd Saraj, Louna Karzoun, Alpay Kose, Mert Akin Insel, Ridvan Yildirim, Ayca Bal Ozturk, Ayse Ceren Calikoglu Koyuncu, Oguzhan Gunduz, Cem Bulent Ustundag   +11 more
wiley   +1 more source

A proteomics investigation of primary human articular chondrocyte isolation. [PDF]

Osteoarthr Cartil Open
Brumwell A, Raheja S, Cawley W, Birkett-Jones E, Orr SE, Todd C, Deehan DJ, Conlon NJ, Trost M, Rice SJ.   +9 more
europepmc   +1 more source

From Bioinks to Functional Tissues and Organs: Advances, Challenges, and the Promise of 3D Bioprinting

Macromolecular Materials and Engineering, EarlyView.
This review explores recent advances in 3D bioprinting, emphasizing printing technologies, bioink design, and emerging strategies such as cryogenic printing. Key challenges in biocompatibility, vascularization, and scalability are discussed, alongside opportunities for clinical translation.
Muhammad Wajid Ullah, Mazhar Ul‐Islam, Adeeb Shehzad, Sehrish Manan, Salman Ul Islam, Atiya Fatima, Abdullah Khamis Al‐Saidi, Mustapha El Hariri El Nokab, Juan Quevedo Sanchez, Khaled O. Sebakhy   +9 more
wiley   +1 more source

Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis. [PDF]

Int J Biol Sci
Chen H, Cui Y, Li J, Duan M, Pi C, Zhou X, Xie J.   +6 more
europepmc   +1 more source

Effects of Genistein on Inflammasome Induced Pancreatic β‐Cell Apoptosis by Dexamethasone

Molecular Nutrition &Food Research, EarlyView.
The possible mechanism of genistein‐mediated protection against dexamethasone‐induced pancreatic β‐cell apoptosis. Genistein decreases the activation of IRE‐1α, resulting in the reduction of sXBP1, JNK, TXNIP, NLRP3, and IL‐1β expression. Genistein inhibits dexamethasone‐induced pancreatic β‐cell apoptosis.
Nattinee Jitprawet, Jatuporn Sujjitjoon, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source

High-mobility network hydrogel microsphere system to combat chondrocyte senescence for enhanced cartilage repair and regeneration. [PDF]

Mater Today Bio
Xu F, Zhuang C, Yao L, Xu Y, Cao Q, Fu Z, Wang L, Zhu Y, Xue D, Zhang N, Yu X, Hu G, Lin F.   +12 more
europepmc   +1 more source