Results 341 to 350 of about 170,603 (392)
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Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

Annals of the Rheumatic Diseases, 2022
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression.
Haiyan Zhang   +13 more
semanticscholar   +1 more source

The chondrocyte

The International Journal of Biochemistry & Cell Biology, 2003
The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement.
Archer, C W, Francis-West, P
openaire   +3 more sources

Molecular characterisation of chondrocytes in autologous chondrocyte implantation

International Journal of Molecular Medicine, 2004
Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the apoptotic index of cells implanted ...
Jiake Xu   +6 more
openaire   +3 more sources

Expression of FSHR in chondrocytes and the effect of FSH on chondrocytes

Biochemical and Biophysical Research Communications, 2018
Chondrocytes express many kinds of hormone receptors. The function of Follicle stimulating hormone (FSH) in the ovary is mediated by FSH receptor (FSHR). FSH receptor (FSHR) is found in many non-ovarian tissues, however it has been unclear if chondrocytes express FSHR.
Guandong Li   +9 more
openaire   +2 more sources

Chondrocyte transplantation

Arthroscopy: The Journal of Arthroscopic & Related Surgery, 1996
The transplantation of chondrocytes as a treatment to repair defects and degeneration in hyaline articular cartilage is being tested in numerous laboratory and clinical settings. This has included transplanting chondrocytes grown in tissue culture that were procured from non-weight-bearing areas of the affected joint to transplanting allografts with ...
D W, Jackson, T M, Simon
openaire   +2 more sources

Autologous Chondrocyte Implantation

The Journal of Bone & Joint Surgery, 2006
Injuries to joint surfaces can result from acute high-impact or repetitive shear and torsional loads to the superficial zone of the articular cartilage architecture. The use of autologous chondrocyte implantation is promising and is associated with several potential long-term benefits.
Jones, D. G., Peterson, L.
openaire   +4 more sources

Catering to chondrocytes

Science Translational Medicine, 2018
An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al ., this issue).
openaire   +3 more sources

Chondrocyte Differentiation

1995
Data obtained while investigating growth plate chondrocyte differentiation during endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis depends on positional signaling mediated by selected homeobox-containing genes and soluble mediators.
R, Cancedda   +2 more
openaire   +2 more sources

A biography of the chondrocyte

Annals of the Rheumatic Diseases, 2008
Significant gaps persist in our understanding of chondrocyte biology. We do not know when, how, or even whether these cells are replenished throughout the normal, human life span. We are taught that as much as 90% of the cartilage is "metabolically inert" interterritorial matrix, but we do not know how this substance is regularly replaced (as it is ...
openaire   +3 more sources

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