Results 191 to 200 of about 244,346 (227)

Transcriptional regulators of chondrocyte hypertrophy

Birth Defects Research Part C: Embryo Today: Reviews, 2008
AbstractCoordinated transition from proliferation to terminal differentiation and hypertrophy of growth plate chondrocytes is required for normal growth of endochondral bones and thus determines final height in humans. Over the last decades, transcription factors of the Sox and Runx families have been shown to be the central regulators of this process.
Lauren A, Solomon, Nathalie G, Bérubé, Frank, Beier   +2 more
openaire   +2 more sources

Morphometric analysis of chondrocyte hypertrophy.

The Journal of Bone & Joint Surgery, 1986
In the hypertrophic zone of the cartilaginous growth plate, chondrocytes enlarge, assume a more spherical shape, and form a population of cells called the hypertrophic chondrocytes. The mechanisms that are involved in the formation of hypertrophic chondrocytes are poorly understood. Cell hypertrophy usually refers to an increase in cell size and volume
J A, Buckwalter, D, Mower, R, Ungar, J, Schaeffer, B, Ginsberg   +4 more
openaire   +2 more sources

MMP-13 is induced during chondrocyte hypertrophy

Journal of Cellular Biochemistry, 2000
During development, mRNA for matrix metalloproteinase-13 (MMP-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. Using chondrocytes from prehypertrophic cartilage of chick embryo sternae, we have examined the relationship between MMP-13 ...
D'Angelo, Marina, Yan, Z., Nooreyazdan, M., Pacifici, Maurizio, Sarment, D. S., Billings, Paul C., Leboy, Phoebe S.   +6 more
openaire   +2 more sources

Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy

Journal of Bone and Mineral Metabolism, 2023
Periostin, an extracellular matrix protein, plays an important role in osteogenesis and is also known to activate several signals that contribute to chondrogenesis. The absence of periostin in periostin knockout mice leads to several disorders such as craniosynostosis and periostitis.
Seiko Ishihara, Risa Usumi-Fujita, Yuki Kasahara, Shuji Oishi, Kana Shibata, Yasuhiro Shimizu, Yuji Ishida, Sawa Kaneko, Makoto Sugiura-Nakazato, Makoto J. Tabata, Jun Hosomichi, Yoshiaki Taniyama, Takashi Ono   +12 more
openaire   +2 more sources

Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy.

Journal of materials chemistry. B, 2021
Co-culture of chondrocytes and mesenchymal stem cells (MSCs) represents an effective way to stimulate the chondrogenesis of MSCs and reduce hypertrophy, but the limited donor site supply and the requirement of two-stage operations are among the major ...
Z. Tang, Yan Lu, Shixin Zhang, Jing Wang, Qiguang Wang, Y. Xiao, Xing‐dong Zhang   +6 more
semanticscholar   +1 more source

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

Journal of Cellular Physiology, 2006
AbstractWe investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent avian sarcoma (RCAS) viral over‐expression of Wnt8c and Wnt9a, upregulated type X collagen (col10a1) and Runx2 mRNA expression thereby inducing chondrocyte hypertrophy ...
Yu-Feng, Dong, Do Y, Soung, Edward M, Schwarz, Regis J, O'Keefe, Hicham, Drissi   +4 more
openaire   +2 more sources

Hypertrophy and physiological death of equine chondrocytes in vitro

Equine Veterinary Journal, 2007
Summary Reasons for performing study : Equine osteochondrosis results from a failure of endochondral ossification during skeletal growth. Endochondral ossification involves chondrocyte proliferation, hypertrophy and death.
Y A, Ahmed, L, Tatarczuch, C N, Pagel, H M, Davies, M, Mirams, E J, Mackie   +5 more
openaire   +2 more sources

Microbiota‐derived lipopolysaccharide retards chondrocyte hypertrophy in the growth plate through elevating Sox9 expression

Journal of Cellular Physiology, 2018
Accumulating data show that the cytotoxicity of bacterial lipopolysaccharides (LPS) from microbiota or infection is associated with many disorders observed in the clinics.
Xin Cheng, Pei-zhi Li, Guang Wang, Yu Yan, Ke Li, B. Brand-Saberi, Xuesong Yang   +6 more
semanticscholar   +1 more source

Chondrocyte hypertrophy requires matrix turnover

2006
abstract only.
Donkelaar, van, C.C., Wilson, W.
openaire   +1 more source

Chondrocyte hypertrophy requires collagen turnover

Matrix Biology, 2006
Donkelaar, van, C.C., Wilson, W.
openaire   +2 more sources