Results 171 to 180 of about 12,394 (186)

Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

Endocrinology, 2023
Abstract Peripheral neuropeptide Y (NPY) has been reported to regulate bone metabolism and homeostasis; however, its potential roles in growth plate chondrogenesis remain unclear. Here, we found that NPY expression decreased during chondrocyte differentiation in vitro and in vivo.
Xiaomin Kang, Xiao Ma, Huixia Li, Xinxin Jin, Xin Gao, Dongxu Feng, Shufang Wu   +6 more
openaire   +2 more sources

Identification and characterization of up-regulated genes during chondrocyte hypertrophy [PDF]

Developmental Dynamics, 1996
Chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type X collagen, alkaline phosphatase, and matrix metalloproteinases. To analyze further the genetic program associated with chondrocyte hypertrophy, we have employed a modification of the polymerase chain reaction-mediated
Maria Nurminskaya, Thomas F Linsenmayer
exaly   +3 more sources

BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base

The International Journal of Developmental Biology, 2003
Defects in the growth and development of the endochondral bones that comprise the cranial base contribute to several craniofacial dysmorphic syndromes. Since Bone Morphogenetic Protein (BMP) signaling regulates chondrocyte differentiation and endochondral ossification in developing long bones, we have tested the hypothesis that BMP signaling also ...
Lillian, Shum, Xibin, Wang, Alex A, Kane, Glen H, Nuckolls   +3 more
openaire   +2 more sources

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

Journal of Cellular Physiology, 2006
AbstractWe investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent avian sarcoma (RCAS) viral over‐expression of Wnt8c and Wnt9a, upregulated type X collagen (col10a1) and Runx2 mRNA expression thereby inducing chondrocyte hypertrophy ...
Yu-Feng, Dong, Do Y, Soung, Edward M, Schwarz, Regis J, O'Keefe, Hicham, Drissi   +4 more
openaire   +2 more sources

Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface

2007
Osteoarthritis (OA) is a complex multifactorial disease confounded by age, genetic factors, and mechanical forces. It is characterized by focal changes in the volume of some cells in the superficial as well as the deeper zones of the cartilage. Ongoing studies suggest that the cell volume increases in response to degradation of the extracellular matrix
Shapiro, I. M., Adams, Christopher S., Srinivas, V., Freeman, T. A.   +3 more
openaire   +1 more source

Chondrocyte hypertrophy requires matrix turnover

2006
abstract only.
Donkelaar, van, C.C., Wilson, W.
openaire   +1 more source

Matrix remodeling is essential for chondrocyte hypertrophy

Journal of Biomechanics, 2006
R.C.C. van Donkelaar, W. Wilson
openaire   +1 more source

Chondrocyte hypertrophy requires collagen turnover

Matrix Biology, 2006
Donkelaar, van, C.C., Wilson, W.
openaire   +2 more sources

Effect of Swell1 on regulating chondrocyte hypertrophy during the condylar osteochondral development process in mice

Biochemical and Biophysical Research Communications, 2022
Yanting Xu, Steve Gf Shen, Jiewen Dai
exaly  

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation

American Journal of Sports Medicine, 2012
Matthias F Pietschmann, Thomas R Niethammer, Annie Horng   +2 more
exaly