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Mitochondrial quality control modulating chondrocyte behavior and fate in knee osteoarthritis: mechanistic insights and therapeutic prospects. [PDF]

Front Immunol
Li Y, Zhong W, Li L, Zhang F, Duan X, Si H.   +5 more
europepmc   +1 more source

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.

Journal of musculoskeletal & neuronal interactions, 2009
S J, Gauci, S B, Golub, L, Tutolo, C B, Little, N A, Sims, E R, Lee, E J, Mackie, A J, Fosang   +7 more
openaire   +1 more source

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
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Transcriptional regulators of chondrocyte hypertrophy

Birth Defects Research Part C: Embryo Today: Reviews, 2008
AbstractCoordinated transition from proliferation to terminal differentiation and hypertrophy of growth plate chondrocytes is required for normal growth of endochondral bones and thus determines final height in humans. Over the last decades, transcription factors of the Sox and Runx families have been shown to be the central regulators of this process.
Lauren A, Solomon, Nathalie G, Bérubé, Frank, Beier   +2 more
openaire   +4 more sources

Morphometric analysis of chondrocyte hypertrophy.

The Journal of Bone & Joint Surgery, 1986
In the hypertrophic zone of the cartilaginous growth plate, chondrocytes enlarge, assume a more spherical shape, and form a population of cells called the hypertrophic chondrocytes. The mechanisms that are involved in the formation of hypertrophic chondrocytes are poorly understood. Cell hypertrophy usually refers to an increase in cell size and volume
J A, Buckwalter, D, Mower, R, Ungar, J, Schaeffer, B, Ginsberg   +4 more
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MMP-13 is induced during chondrocyte hypertrophy

Journal of Cellular Biochemistry, 2000
During development, mRNA for matrix metalloproteinase-13 (MMP-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. Using chondrocytes from prehypertrophic cartilage of chick embryo sternae, we have examined the relationship between MMP-13 ...
D'Angelo, Marina, Yan, Z., Nooreyazdan, M., Pacifici, Maurizio, Sarment, D. S., Billings, Paul C., Leboy, Phoebe S.   +6 more
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Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

Endocrinology, 2023
Abstract Peripheral neuropeptide Y (NPY) has been reported to regulate bone metabolism and homeostasis; however, its potential roles in growth plate chondrogenesis remain unclear. Here, we found that NPY expression decreased during chondrocyte differentiation in vitro and in vivo.
Xiaomin Kang, Xiao Ma, Huixia Li, Xinxin Jin, Xin Gao, Dongxu Feng, Shufang Wu   +6 more
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Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy

Journal of Bone and Mineral Metabolism, 2023
Periostin, an extracellular matrix protein, plays an important role in osteogenesis and is also known to activate several signals that contribute to chondrogenesis. The absence of periostin in periostin knockout mice leads to several disorders such as craniosynostosis and periostitis.
Seiko Ishihara, Risa Usumi-Fujita, Yuki Kasahara, Shuji Oishi, Kana Shibata, Yasuhiro Shimizu, Yuji Ishida, Sawa Kaneko, Makoto Sugiura-Nakazato, Makoto J. Tabata, Jun Hosomichi, Yoshiaki Taniyama, Takashi Ono   +12 more
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Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

Journal of Cellular Physiology, 2006
AbstractWe investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent avian sarcoma (RCAS) viral over‐expression of Wnt8c and Wnt9a, upregulated type X collagen (col10a1) and Runx2 mRNA expression thereby inducing chondrocyte hypertrophy ...
Yu-Feng, Dong, Do Y, Soung, Edward M, Schwarz, Regis J, O'Keefe, Hicham, Drissi   +4 more
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