Results 161 to 170 of about 109,571 (195)

Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features. [PDF]

Sci Rep, 2020
Geurts J, Nasi S, Distel P, Müller-Gerbl M, Prolla TA, Kujoth GC, Walker UA, Hügle T.   +7 more
europepmc   +1 more source

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction. [PDF]

Bone Res, 2019
Lian C, Wang X, Qiu X, Wu Z, Gao B, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.   +14 more
europepmc   +1 more source

Emerging molecular mechanisms of the ECM-exosome growth-plate axis in idiopathic short stature. [PDF]

Front Cell Dev Biol
Piao L, Wang H, Zhang Q, Li J, Sun H, Sun R, Li M, Wang Y.   +7 more
europepmc   +1 more source

Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis. [PDF]

Bone Res
Wells LM, Keen JAC, Sharma A, Marr N, Hansen R, Pereira JS, Roe T, Roberts HC, Oppermann U, Clarke PA, Pitsillides AA, Roberts SJ.   +11 more
europepmc   +1 more source

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis [PDF]

Cell, 2004
Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Xiangli Yang, John Shelton, Gérard Karsenty   +2 more
exaly   +5 more sources

Consequences of chondrocyte hypertrophy on osteoarthritic cartilage: potential effect on angiogenesis [PDF]

Osteoarthritis and Cartilage, 2013
The aim of this study was to investigate the link between the hypertrophic phenotype of chondrocytes and angiogenesis in osteoarthritis (OA) and more particularly to demonstrate that OA hypertrophic chondrocytes potentially express a phenotype promoting angiogenesis through the expression of factors controlling endothelial cells migration, invasion and
Yves Henrotin, A Bellahcene
exaly   +5 more sources

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Transcriptional regulators of chondrocyte hypertrophy

Birth Defects Research Part C: Embryo Today Reviews, 2008
AbstractCoordinated transition from proliferation to terminal differentiation and hypertrophy of growth plate chondrocytes is required for normal growth of endochondral bones and thus determines final height in humans. Over the last decades, transcription factors of the Sox and Runx families have been shown to be the central regulators of this process.
Mélina Bellini, Nathalie Berube, Lauren A Solomon   +2 more
exaly   +3 more sources

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? [PDF]

Osteoarthritis and Cartilage, 2012
Item does not contain fulltextOBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a conceptual model of primary OA development ...
W B van den Berg
exaly   +2 more sources