Results 301 to 310 of about 48,883 (320)
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Annals of Plastic Surgery, 2000
Recently proposed procedures for in vitro generation of new cartilage may be difficult to perform in humans because so many chondrocytes are needed for tissue engineering. In this study the authors investigated new, efficient, low-cost techniques for the isolation and culture of chondrocytes from the ear cartilage of the rabbit.
Sung Yurl Yang +6 more
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Recently proposed procedures for in vitro generation of new cartilage may be difficult to perform in humans because so many chondrocytes are needed for tissue engineering. In this study the authors investigated new, efficient, low-cost techniques for the isolation and culture of chondrocytes from the ear cartilage of the rabbit.
Sung Yurl Yang +6 more
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Cell cycle genes in chondrocyte proliferation and differentiation
Matrix Biology, 1999Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell
Todd Leask +8 more
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FBLN1 promotes chondrocyte proliferation by increasing phosphorylation of Smad2
Journal of Orthopaedic Science, 2022The role of fibulin-1 or FBLN1 in chondrocyte proliferation has not been reported so far. In this study, we aimed to verify whether FBLN1 promotes chondrocyte proliferation in elderly patients with knee osteoarthritis by phosphorylating Smad2.Chondrocytes were isolated from cartilage samples collected from elderly patients with osteoarthritis (n = 6 ...
Gang Xu +3 more
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Chondrocyte Proliferation and Differentiation
2011The skeletal elements of the axial and appendicular skeleton are preformed as cartilage templates by a mechanism called endochondral ossification. During this process, a cartilage template is formed in which chondrocytes proliferate and differentiate into hypertrophic chondrocytes and are gradually replaced by bone.
Manuela Wuelling, Andrea Vortkamp
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Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation
Journal of Bone and Mineral Metabolism, 2010Runx2 plays important roles in the regulation of chondrocyte differentiation and proliferation; however, the Runx2 target molecules still remain to be investigated. We searched the genes upregulated by the introduction of Runx2 into Runx2(-/-) chondrocytes using microarray and found that Tcf7 is upregulated by Runx2.
Satoshi Rokutanda +7 more
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Suppression of growth plate chondrocyte proliferation by corticosteroids
Pediatric Nephrology, 2000Growth depression is a side effect of high-dose glucocorticoid therapy in childhood. It is partially mediated by alterations of the somatotropic hormone axis and partially by direct local effects on growth plate chondrocytes. The mechanisms of interaction of corticosteroids and somatotropic and calciotropic hormones at the cellular level were recently ...
Julian Rodriguez +5 more
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Inhibition effect of osthole on proliferation of rat chondrocytes
Journal of Chinese Integrative Medicine, 2012To investigate the effects of osthole on chondrocyte proliferation in vitro.Primary rat chondrocytes were isolated from the femoral head of newborn rats using collagenase digestion and cultured in Dulbecco's modified Eagle's medium. The proliferation of primary chondrocytes was assessed in second-passage cultures using cell counting kit-8 and the ...
Song-Pu Wei +6 more
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Effect of 17β-estradiol on the proliferation of condylar chondrocytes.
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2021To study the effects of 17β-estradiol (E2) on the regulation of the proliferation of condylar chondrocytes and provide a preliminary discussion on the role of phosphorylate-mammalian target of rapamycin (p-mTOR) in this regulatory process.Condylar chondrocytes were isolated from 6-week-old female rats for primary culture.
Shuai Zhang +4 more
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Runx3 regulates chondrocyte phenotype by controlling multiple genes involved in chondrocyte proliferation and differentiation [PDF]
Molecular Biology Reports, 2020 Chondrocytes are the sole cell type present within cartilage, and play pivotal roles in controlling the formation and composition of health cartilage. Chondrocytes maintain cartilage homeostasis through proliferating, differentiating and synthesizing different types of extracellular matrices.
Zhenwei Zhou, Baojin Yao, Daqing Zhao
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Influence of ion channels on the proliferation of human chondrocytes
Biorheology: The Official Journal of the International Society of Biorheology, 2002The goal of the study was to examine connections between ion channel activity and the proliferation of human chondrocytes. Chondrocytes were isolated form human osteoarthritic knee joint cartilage. In this study the concentration‐dependent influence of the ion channel modulators tetraethylammonium (TEA), 4‐aminopyridine (4‐AP), 4′,4′ diisothiocyanato ...
David, Wohlrab +3 more
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