Results 311 to 320 of about 1,182,907 (370)

Platelet Supernatant Promotes Proliferation of Auricular Chondrocytes and Formation of Chondrocyte Mass

Annals of Plastic Surgery, 2000
Recently proposed procedures for in vitro generation of new cartilage may be difficult to perform in humans because so many chondrocytes are needed for tissue engineering. In this study the authors investigated new, efficient, low-cost techniques for the isolation and culture of chondrocytes from the ear cartilage of the rabbit.
S Y, Yang, S T, Ahn, J W, Rhie, K Y, Lee, J H, Choi, B J, Lee, G T, Oh   +6 more
openaire   +2 more sources

LncRNA SNHG5 promotes chondrocyte proliferation and inhibits apoptosis in osteoarthritis by regulating miR-10a-5p/H3F3B axis

Connective Tissue Research, 2020
Background Osteoarthritis (OA) is a common degenerative joint disease in the elderly. Increasing evidence suggested that long non-coding RNAs (lncRNAs) played vital roles in OA progression.
Housen Jiang, Hui Pang, Peigang Wu, Zhenhao Cao, Zhong Li, Xue-min Yang   +5 more
semanticscholar   +1 more source

Autologous chondrocyte implantation: cells phenotype and proliferation analysis

Knee Surgery, Sports Traumatology, Arthroscopy, 2001
AbstractThe phenotype and proliferation of human chondrocytes in culture were analyzed before they were implanted as autologous graft in cartilage lesions. During ten autologous chondrocyte implantations in articular cartilage lesions of the knee in ten patients, small amounts of cells to be implanted were collected and analyzed by morphology ...
A, Gigante, C, Bevilacqua, C, Zara, M, Travasi, C, Chillemi   +4 more
openaire   +2 more sources

Cell cycle genes in chondrocyte proliferation and differentiation

Matrix Biology, 1999
Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell
F, Beier, T A, Leask, S, Haque, C, Chow, A C, Taylor, R J, Lee, R G, Pestell, R T, Ballock, P, LuValle   +8 more
openaire   +2 more sources

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes

Biochemical Pharmacology, 2005
Rat primary chondrocytes express the lysophosphatidic acid (LPA) receptor, LPA1, LPA3, but not LPA2. When chondrocytes were stimulated with LPA, phospholipase C-mediated cytosolic calcium increase was dramatically induced. LPA also stimulated two kinds of mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK) and p38 kinase in ...
Mi-Kyoung, Kim, Ha-Young, Lee, Kyoung Sun, Park, Eun Ha, Shin, Seong Ho, Jo, Jeanho, Yun, Sung Won, Lee, Young Hyun, Yoo, Yun-Sik, Lee, Suk-Hwan, Baek, Yoe-Sik, Bae   +10 more
openaire   +2 more sources

GDF15 enhances proliferation of aged chondrocytes by phosphorylating SMAD2

Journal of Orthopaedic Science, 2022
Aging is one of the primary factors influencing development of osteoarthritis, and the TGF-β pathway plays an important role in age-related osteoarthritis. Specifically, GDF15 phosphorylates SMAD2/3 in the TGF-β pathway to inhibit cardiomyocyte hypertrophy, and promote proliferation of chondrocytes.
Dongming, Wang, Xiaochun, Wei, Xiang, Geng, Pengcui, Li, Lu, Li   +4 more
openaire   +2 more sources

Suppression of growth plate chondrocyte proliferation by corticosteroids

Pediatric Nephrology, 2000
Growth depression is a side effect of high-dose glucocorticoid therapy in childhood. It is partially mediated by alterations of the somatotropic hormone axis and partially by direct local effects on growth plate chondrocytes. The mechanisms of interaction of corticosteroids and somatotropic and calciotropic hormones at the cellular level were recently ...
G, Klaus, C, Jux, P, Fernandez, J, Rodriguez, R, Himmele, O, Mehls   +5 more
openaire   +2 more sources

Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation

Biochemical and Biophysical Research Communications, 2006
Rat primary chondrocytes express the sphingosine-1-phosphate (S1P) receptor, S1P(2), S1P(3), S1P(4), but not S1P(1). When chondrocytes were stimulated with S1P or phytosphingosine-1-phosphate (PhS1P, an S1P(1)- and S1P(4)-selective agonist), phospholipase C-mediated cytosolic calcium increase was dramatically induced.
Mi-Kyoung, Kim, Ha Young, Lee, Jong-Young, Kwak, Joo-In, Park, Jeanho, Yun, Yoe-Sik, Bae   +5 more
openaire   +2 more sources

Solution viscosity regulates chondrocyte proliferation and phenotype during 3D culture.

Journal of materials chemistry. B, 2019
Cells are surrounded by an extracellular matrix (ECM), which controls cellular functions through biological or physicochemical cues. In particular, cartilage tissues have abundant ECM that is viscoelastic and provides the necessary signals for the ...
Kyubae Lee, Yazhou Chen, Xiaomeng Li, Yongtao Wang, N. Kawazoe, Yingnan Yang, Guoping Chen   +6 more
semanticscholar   +1 more source

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis.

Biochemical Journal, 2018
The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for osteoarthritis (OA).
Yubao Liu, Rui Zou, Zhen Wang, C. Wen, Fan Zhang, Fuqing Lin   +5 more
semanticscholar   +1 more source