Results 311 to 320 of about 48,883 (320)

Is the proliferation of human chondrocytes regulated by ionic channels?

Journal of Orthopaedic Science, 2001
As in cells in all living cell systems, human chondrocytes are provided with a membrane potential. The existence of ion channels in the cell membrane is an essential prerequisite for the development of membrane potential. In nonhuman chondrocytes, different ion channels have already been identified. An association between potassium channel activity and
David Wohlrab, Johannes Wohlrab, Werner Hein, H. Reichel   +3 more
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GDF15 enhances proliferation of aged chondrocytes by phosphorylating SMAD2

Journal of Orthopaedic Science, 2022
Aging is one of the primary factors influencing development of osteoarthritis, and the TGF-β pathway plays an important role in age-related osteoarthritis. Specifically, GDF15 phosphorylates SMAD2/3 in the TGF-β pathway to inhibit cardiomyocyte hypertrophy, and promote proliferation of chondrocytes.
Pengcui Li, Dongming Wang, Lu Li, Xiang Geng, Xiaochun Wei   +4 more
openaire   +2 more sources

Modulation of chondrocyte proliferation by ascorbic acid and BMP‐2

Journal of Cellular Physiology, 1998
Chondrocytes show an unusual ability to thrive under serum-free conditions as long as insulin, thyroxine, and cysteine are present. Studies with sternal chondrocytes from chick embryos indicate that thymidine incorporation in chondrocytes cultured under serum-free conditions is 30-50% of that seen with fetal bovine serum (FBS).
Bruce J. Shenker, Rachel A. Venezian, Phoebe S. Leboy, Sugandha Datar   +3 more
openaire   +3 more sources

Stimulation by Glucocorticoids of the Differentiated Phenotype of Chondrocytes and the Proliferation of Rabbit Costal Chondrocytes in Culture1

The Journal of Biochemistry, 1985
Hydrocortisone stimulated glycosaminoglycan (GAG) synthesis, a characteristic of the cartilage phenotype, of rabbit costal chondrocytes in confluent quiescent culture, as judged by the incorporations of [35S]sulfate and [3H]glucosamine. Hydrocortisone also stimulated incorporation of [3H]serine into proteoglycan.
Masaharu Takigawa, Fujio Suzuki, Teruko Takano   +2 more
openaire   +3 more sources

Autologous chondrocyte implantation: cells phenotype and proliferation analysis

Knee Surgery, Sports Traumatology, Arthroscopy, 2001
AbstractThe phenotype and proliferation of human chondrocytes in culture were analyzed before they were implanted as autologous graft in cartilage lesions. During ten autologous chondrocyte implantations in articular cartilage lesions of the knee in ten patients, small amounts of cells to be implanted were collected and analyzed by morphology ...
Claudia Bevilacqua, Antonio Gigante, Miriam Travasi, Claudio Zara, Claudio Chillemi   +4 more
openaire   +3 more sources

Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients

Bone, 2006
Multiple hereditary exostoses (MHE) is an autosomal dominant skeletal disorder caused by mutations in one of the two EXT genes and characterized by multiple osteochondromas that generally arise near the ends of growing long bones. Defective endochondral ossification is likely to be involved in the formation of osteochondromas.
Emmanuel de Margerie, Jacky Bonaventure, Sarah Cormier, Caroline Silve, Louise Zylberberg, Catherine Benoist-Lasselin, Jean-Francois Mallet, Martine LeMerrer, Gisèle Nicolas, Laurence Legeai-Mallet, Linda Gibbs, Arnold Munnich   +11 more
openaire   +3 more sources

Inhibition of Proliferation of Chondrocytes by Specific Receptors in Response to Retinoids

Biochemical and Biophysical Research Communications, 1996
All-trans retinoic acid inhibited the proliferation of chondrocytes derived from rat xiphoid cartilage when added to the culture medium at 10(-10)-10(-8) M. Proliferation of mouse clonal osteoblastic cells was also inhibited to a significant extent by all-trans retinoic acid.
Kazuyasu Nakaya, Soichi Kojima, Shigehisa Hirose, Shigeo Nakajo, Hiromi Hagiwara, Atsuto Inoue   +5 more
openaire   +3 more sources

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes

Biochemical Pharmacology, 2005
Rat primary chondrocytes express the lysophosphatidic acid (LPA) receptor, LPA1, LPA3, but not LPA2. When chondrocytes were stimulated with LPA, phospholipase C-mediated cytosolic calcium increase was dramatically induced. LPA also stimulated two kinds of mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK) and p38 kinase in ...
Mi-Kyoung Kim, Seong Ho Jo, Yoe-Sik Bae, Sung Won Lee, Kyoung Sun Park, Jeanho Yun, Eun Ha Shin, Suk-Hwan Baek, Young Hyun Yoo, Ha Young Lee, Yun-Sik Lee   +10 more
openaire   +3 more sources

Isolation and In Vitro Proliferation of Chondrocytes, Tenocytes, and Ligament Cells

2003
In recent years it has become possible to grow large numbers of selected cell types in vitro from relatively small tissue samples. This capability has served as the foundation for using autogenous, as well as allogeneic, cells expanded in culture for engineering tissues that display little potential for spontaneous regeneration. Cartilage, tendons, and
Myron Spector, Sonya Shortkroff
openaire   +3 more sources

INFLUENCE OF ELECTROMAGNETIC FIELDS ON CHONDROCYTE PROLIFERATION IN VITRO

2007
NICOLIN, VANESSA, NARDUCCI P, MARTINELLI B.   +2 more
openaire   +1 more source