Results 121 to 130 of about 213,570 (404)
Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. [PDF]
, 1994 Epiphyseal chondrocytes cultured in a medium containing 10% serum may be maintained as three dimensional aggregates and differentiate terminally into hypertrophic cells.
Ballock, RT, Reddi, AH
core
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]
, 2010 Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P. +9 more
core +1 more source
Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model [PDF]
, 2016 A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. We constructed a multiscale mathematical model of the process with three components: cellular, chemical, and mechanical.
arxiv +1 more source
The role of the chondrocyte in osteoarthritis [PDF]
Arthritis & Rheumatism, 2000 Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage or to sites of trauma, repetitive mechanical injury has been proposed as the critical signal for the initiation and progression of OA. It is now generally accepted that
openaire +3 more sources
Potassium channels in articular chondrocytes [PDF]
Channels, 2012 Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells ...
Mobasheri, A +5 more
openaire +4 more sources
Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis
Advanced Healthcare Materials, EarlyView.An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back +3 more
wiley +1 more source
Scientific Reports, 2015 Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was reciprocally downregulated in osteoarthritic degenerated cartilage.
M. Koike +13 more
semanticscholar +1 more source
BMC Musculoskeletal Disorders, 2012 Background Like all mammalian cells, normal adult chondrocytes have a limited replicative life span, which decreases with age. To facilitate the therapeutic use of chondrocytes from older donors, a method is needed to prolong their life span.
Sato Masato +8 more
doaj +1 more source
Annexin A6 regulates catabolic events in articular chondrocytes via the modulation of NF-κB and Wnt/ß-catenin signaling. [PDF]
PLoS ONE, 2018 Annexin A6 (AnxA6) is expressed in articular chondrocytes at levels higher than in other mesenchymal cell types. However, the role of AnxA6 in articular chondrocytes is not known. Here we show that complete lack of AnxA6 functions resulted in increased ß-
Takeshi Minashima, Thorsten Kirsch
doaj +1 more source
Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA [PDF]
, 2015 Objective: To use deep sequencing to identify novel microRNAs in human osteoarthritic cartilage which have a functional role in chondrocyte phenotype or function.
Aigner +59 more
core +1 more source