Results 151 to 160 of about 213,570 (404)

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes [PDF]

, 2015
Zhao Wang is funded on a China Scholarships PhD Studentship. Jerome Irianto was supported on a project grant from The Wellcome Trust (ref no. 084717)
Baaijens, Bader, Borghetti, Bush, Bush, Bush, Bush, Cantiello, Chalut, Chao, Chen, Dahl, Darling, Erickson, Fletcher, Guilak, Guilak, Guilak, Hopewell, Huttu, Irianto, J. Irianto, Jones, Kerrigan, Kerrigan, Kerrigan, Knight, Knight, Koay, Korhonen, Leipzig, Li, Lohr, M.M. Knight, McArthur, Mobasheri, Moran, Ohashi, Okada, Okumura, Ordaz, Pajerowski, Phan, Pravincumar, Pritchard, Quist, Qusous, Qusous, S. Kazun, Sato, Souza, Stewart, Theret, Trickey, Trickey, Turunen, Urban, Urban, Van Inwegen, Voets, W. Wang, Z. Wang   +61 more
core   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain

Arthritis Research & Therapy, 2014
IntroductionNerve growth factor (NGF) level is increased in osteoarthritis (OA) joints and is involved in pain associated with OA. Stimuli responsible for NGF stimulation in chondrocytes are unknown.
É. Pecchi, S. Priam, M. Gosset, A. Pigenet, L. Sudre, Marie-Charlotte Laiguillon, F. Berenbaum, X. Houard   +7 more
semanticscholar   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Reaction-Diffusion-Delay Model for EPO/TNF-$α$? Interaction in Articular Cartilage Lesion Abatement [PDF]

arXiv, 2011
Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region ...
arxiv  

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage

European Journal of Histochemistry, 2015
The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage.
K. Fujikawa, T. Yokohama-Tamaki, T. Morita, O. Baba, C. Qin, S. Shibata   +5 more
doaj   +1 more source

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung, Chun, Hyelim, Lopez, Noah, Lyons, Karen M, Razavi, Peyman, Sadik, Joshua Elyahu, Shirazyan, Anna, Wang, Weiguang   +7 more
core  

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Effects of 5-aza-2´-deoxycytidine on primary human chondrocytes from osteoarthritic patients.

PLoS ONE, 2020
Chondrocytes, comparable to many cells from the connective tissue, dedifferentiate and end up in a similar fibroblastoid cell type, marked by the loss of the specific expression pattern.
Shirin Kadler, Özlem Vural, Jennifer Rosowski, Luzia Reiners-Schramm, Roland Lauster, Mark Rosowski   +5 more
doaj   +1 more source