Results 171 to 180 of about 222,465 (345)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Chondrocyte Differentiation of Human Endometrial Gland‐Derived MSCs in Layered Cell Sheets [PDF]

, 2013
Waki Sekine, Yuji Haraguchi, Tatsuya Shimizu, Masayuki Yamato, Akihiro Umezawa, Teruo Okano   +5 more
openalex   +1 more source

Modeling and Simulation of the Effects of Cyclic Loading on Articular Cartilage Lesion Formation

, 2013
We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al.
Ayati, Bruce P., Brouillete, Marc J., Graham, Jason M., Martin, James A., Ramakrishnan, Prem S., Wang, Xiayi   +5 more
core  

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts

Advanced Science, EarlyView.
Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Stephanie E. Schneider, Adrienne K. Scott, Katie M. Gallagher, Emily Y. Miller, Soham Ghosh, Corey P. Neu   +5 more
wiley   +1 more source

Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression

, 1999
MB Goldring, Francis Bérenbaum
openalex   +1 more source

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, EarlyView.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

The dependence of autologous chondrocyte transplantation on varying cellular passage, yield and culture duration

, 2011
Gian M. Salzmann, Martin Sauerschnig, Markus T. Berninger, Theresa Kaltenhauser, Martin Schönfelder, Stephan Vogt, Gabriele Wexel, Thomas Tischer, Norbert P. Südkamp, Philipp Niemeyer, Andreas B. Imhoff, Philip B. Schöttle   +11 more
openalex   +2 more sources

The Critical Role of Hypoxia in the Re-Differentiation of Human Articular Chondrocytes [PDF]

, 2022
Carlos Martínez-Armenta, Carlos Suárez-Ahedo, Anell Olivos‐Meza, María Carmen Camacho-Rea, Laura E. Martínez-Gómez, Guadalupe Elizabeth Jiménez-Gutiérrez, Gabriela Angélica Martínez‐Nava, Luis E. Gómez-Quiroz, Carlos Pineda, Alberto López-Reyes   +9 more
openalex   +1 more source

Anti‐Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration

Advanced Science, EarlyView.
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen, Hao Han, Yuhao Zhang, Longyu Li, Zhishuo Wang, Jiaming Zhang, Liang Han, Hongwei Kou, Guowei Shang, Chunfeng Shang, Zikuan Leng, Keya Mao, Chengwei Li, Lin Jin, Hongjian Liu   +14 more
wiley   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source