Results 171 to 180 of about 216,956 (381)

TBBPA exposure causes cartilage cell damage in both in vitro and in vivo models

Ecotoxicology and Environmental Safety
Tetrabromobisphenol A (TBBPA) is a widely used flame retardant. TBBPA is a persistent pollutant that is difficult to degrade and causes sustained pollution to the environment.
Bohao Yin, Chenjun Liu, Hui Sun, Wei Zhang   +3 more
doaj  

Decoding Cytokine Dynamics: Wharton’s Jelly Stromal Cells and Chondro-Differentiates in PHA-Stimulated Co-Culture

Cells
Introduction: Articular cartilage damage presents a significant clinical challenge, with limited options for effective regeneration. Mesenchymal stromal cells (MSCs) derived from Wharton’s jelly (WJ) are a promising cell source for cartilage repair due ...
Raja Sundari Meenakshi Sundaram, Secunda Rupert, Prasanna Srinivasan, Jeswanth Sathyanesan, Kavitha Govarthanan, Naveen Jeyaraman, Swaminathan Ramasubramanian, Madhan Jeyaraman, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn   +10 more
doaj   +1 more source

Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes [PDF]

, 1988
Sonia B. Jakowlew, Pamela J. Dillard, Michael B. Sporn, Anita B. Roberts   +3 more
openalex   +1 more source

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes

Frontiers in Medicine
Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, and various other contributing factors. The complex interplay of cartilage damage, loss, and impaired repair mechanisms remains a critical and formidable aspect of OA ...
Qingyuan Yu, Yanan Xiao, Mengqi Guan, Guohui Zhou, Xianshuai Zhang, Jianan Yu, Mingze Han, Wei Yang, Yan Wang, Zhenhua Li   +9 more
openaire   +3 more sources

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Effects of matrix macromolecules on chondrocyte gene expression: synthesis of a low molecular weight collagen species by cells cultured within collagen gels. [PDF]

, 1982
G J Gibson, Seth L. Schor, Michael E. Grant   +2 more
openalex   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Isolation and characterization of proteoglycans from chick limb bud chondrocytes grown in vitro.

, 1976
Vincent Hascall, Theodore R. Oegema, Martin L. Brown, Arnold I. Caplan   +3 more
openalex   +1 more source

Differential localization of mRNAs of collagen types I and II in chick fibroblasts, chondrocytes, and corneal cells by in situ hybridization using cDNA probes. [PDF]

, 1986
Miyuki Hayashi, Y Ninomiya, J. Parsons, K. HAYASHI, Bjørn R. Olsen, Robert L. Trelstad   +5 more
openalex   +1 more source

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression

Advanced Science, EarlyView.
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv, Xiang Zhao, Songsong Teng, Xinmeng Jin, Ying Zhou, Yueyang Sun, Hao Pei, Zuoqin Yan, Chunhui Ma   +8 more
wiley   +1 more source