Results 181 to 190 of about 213,570 (404)
Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
wiley +1 more source
Advanced Science, EarlyView.The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li +10 more
wiley +1 more source
Polyphenols suppress inducible oxidative stress in human osteoarthritic and bovine chondrocytes
Osteoarthritis and Cartilage Open, 2020 Reactive oxygen species (ROS) and nitric oxide (NO) have been implicated in chondrocyte senescence and cartilage aging, pathogenesis of osteoarthritis (OA), and rheumatoid arthritis.
Haruyo Yagi +2 more
doaj
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
Aggregate, EarlyView.This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail +5 more
wiley +1 more source
An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis [PDF]
arXivWe develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion.
arxiv
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt +4 more
wiley +1 more source
Pig articular cartilage in organ culture. Effect of enzymatic depletion of the matrix on response of chondrocytes to complement-sufficient antiserum against pig erythrocytes. [PDF]
, 1974 S J Millroy, A. Robin Poole
openalex +1 more source
PLoS ONEOsteoarthritis (OA) is a chronic degenerative disease that primarily includes articular cartilage destruction and inflammatory reactions, and effective treatments for this disease are still lacking.
Peng Li +4 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie +11 more
wiley +1 more source
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
Genes and DiseasesChondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders our understanding of the pathogenesis of osteoarthritis (OA).
Changyuan Huang +9 more
doaj