Results 211 to 220 of about 171,876 (350)

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

, 2018
Cheng Wang, Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Andrew Tai, Wilson Cheuk Wing Chan, Rebecca Lo, Keith K. H. Leung, Nelson W. F. Dung, Nobuyuki Itoh, Michael Q. Zhang, Danny Chan, Kathryn S.E. Cheah   +12 more
openalex   +1 more source

High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

, 2021
Ben Wang, Yifeng Shi, Jiaoxiang Chen, Zhenxuan Shao, Libin Ni, Yan Lin, Yaosen Wu, Naifeng Tian, Yifei Zhou, Liaojun Sun, Aimin Wu, Zhenghua Hong, Xiangyang Wang, Xiaolei Zhang   +13 more
openalex   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Crotonylation-related gene <i>GCDH</i> promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation. [PDF]

Front Nutr
Di J, Guo Z, Di Y, Zhang L, Qin Y, Wang F, Xiang C.   +6 more
europepmc   +1 more source

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

Developmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco, Maha Essaidi, Elijah Barnes, Ashley Williams, Karin Vancíková, Margot C. Labberté, Pieter Brama, Niamh C. Nowlan, Joel D. Boerckel   +8 more
wiley   +1 more source

Engineered MSC‐sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis [PDF]

Kai Feng, Jiashuo Liu, Liangzhi Gong, Teng Ye, Zhengsheng Chen, Yang Wang, Qing Li, Xuetao Xie   +7 more
openalex   +1 more source

SPONDYLOEPIPHYSEAL DYSPLASIA CONGENITA: MORPHOLOGICAL AND BIOCHEMICAL STUDIES IN CULTURED CHONDROCYTES [PDF]

, 1989
Melinda A. Beck, Konrad B. Becker, J Spranger   +2 more
openalex   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

The Role of THBS-3 in the Regulation of Cartilage Angiogenesis and Fibrosis Via the TGF-β/Smad2/3 Pathway in Osteoarthritis. [PDF]

Cartilage
Yan J, Mobasheri A, Zhu X, Lu H, Wang Y, Wang S, Zhang Z, Zhao Y.   +7 more
europepmc   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source