Results 221 to 230 of about 101,193 (316)

Mitochondrial dysfunction activates ADAMTS-5 expression via mt-dsRNA-PKR-Spi-1 axis in osteoarthritic chondrocytes. [PDF]

iScience
Mu Y, Yan S, Wang Y, Liang B, Tang R, Yang H, Ma L, Zhang Y, Li D.   +8 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

Piezo1 in hypertrophic chondrocytes regulates osteoclastogenesis in endochondral ossification. [PDF]

Int J Biol Sci
Tschaffon-Müller MEA, Schoppa A, Eckl F, Brylka LJ, Haffner-Luntzer M, Yorgan TA, Dieterich S, Kölbl C, Amling M, Schinke T, Ignatius A.   +10 more
europepmc   +1 more source

Exploiting Device Deformability for Fluid and Particle Manipulation

Small, EarlyView.
Deformable devices enable fluid and particle manipulation modes that are inaccessible to rigid platforms. This review examines soft materials and architectures that translate controlled deformation into microscale fluid operations such as pumping, valving, mixing, and particle handling.
Zhiyang Hong, Xiaoyue Kang, Dan Yuan, Nam‐Trung Nguyen, Jun Zhang   +4 more
wiley   +1 more source

Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity. [PDF]

Proc Natl Acad Sci U S A
Liao J, He Y, Zhang C, Qian Q, Huang Y, Zhang Q, Shen P, Zhou C, Wu M, Chen G.   +9 more
europepmc   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

Supramolecular self-assembled polyphenol nanoparticles alleviate osteoarthritis by inhibiting chondrocyte ferroptosis. [PDF]

Mater Today Bio
Wu Z, Shi G, Li L, Piao Z, Hao Z, Chen R, Li Z, Li H, Huang Y, Chen J, Zhang Z, Guo L, Dong M, Wang Y, Du J, Li J.   +15 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Targeting TLR4/non-canonical NF-κB pathway by Bushen Bitong recipe enhances BMSCs-based cartilage repair in osteoarthritis. [PDF]

Biochem Biophys Rep
Xiang W, Xiang C, Islam A, Yi L, Ouyang Z, Fang R.   +5 more
europepmc   +1 more source