Results 221 to 230 of about 231,673 (393)

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis. [PDF]

Cell Death Dis
Liu B, Liang Y, Wang C, Weng Z, Yang Y, Shi Y, Zhang C.   +6 more
europepmc   +1 more source

Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo.

Acta Biomaterialia, 2018
Yuanheng Yang, Hang Lin, He Shen, Bing Wang, G. Lei, R. Tuan   +5 more
semanticscholar   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Combination of hypoxia and hyperosmolarity reduces <i>in vitro</i> chondrocyte de-differentiation. [PDF]

Front Vet Sci
De Angelis E, Saleri R, Marcotti F, Ferrari L, Cavalli V, Di Lecce R, Zoboli M, Ravanetti F, Passeri B, Martelli P, Borghetti P.   +10 more
europepmc   +1 more source

Proteochondroitin sulfate synthesis in subcultured chick embryo tibial chondrocytes.

, 1982
J.J. Kim, H. Edward Conrad
openalex   +1 more source

Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair

Journal of dentistry research, 2017
R. Hinton, Y. Jing, J. Jing, J.Q. Feng
semanticscholar   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Mitochondrial transplantation for osteoarthritis: from molecular mechanisms to clinical translation. [PDF]

Front Immunol
Liu Y, Liu Y, Zhang N, An H, Mi L, Gao Y, Xu K.   +6 more
europepmc   +1 more source

LINC01534 promotes the aberrant metabolic dysfunction and inflammation in IL-1β-simulated osteoarthritic chondrocytes by targeting miR-140-5p

, 2019
Wei Wei, Shaoxuan He, Zhihua Wang, Junjie Dong, Dong Xiang, Yunxuan Li, Lirong Ren, Nannan Kou, Jia Lv   +8 more
openalex   +1 more source