Results 11 to 20 of about 21,815 (286)

Osteoarthritis background therapy: current view on the glucosamine and chondroitin therapy

Современная ревматология, 2021
The article highlights the current status of symptomatic slow-acting drugs (SYSADOA) in osteoarthritis (OA). Mechanism of action, clinical studies data on the effectiveness of glucosamine (GA) and chondroitin sulfate (CS) and their combinations in OA ...
L. I. Alekseeva, A. M. Lila
doaj   +1 more source

Chondroitin for osteoarthritis [PDF]

Cochrane Database of Systematic Reviews, 2015
Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review.To evaluate the benefit and harm of oral ...
Jasvinder A, Singh, Shahrzad, Noorbaloochi, Roderick, MacDonald, Lara J, Maxwell   +3 more
openaire   +2 more sources

Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthritis and nonspecific back pain

Современная ревматология, 2023
The combined use of drugs with different mechanisms of action is the main principle of musculoskeletal pain control in rheumatic diseases. However, there are few studies evaluating the efficacy of this approach in real practice.Objective: to determine ...
A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, S. A. Yanchenkova   +37 more
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Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2003
We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. We report
Hiroshi, Kitagawa, Tomomi, Izumikawa, Toru, Uyama, Kazuyuki, Sugahara   +3 more
openaire   +2 more sources

Chondroitin Sulfate Protects the Liver in an Experimental Model of Extra-Hepatic Cholestasis Induced by Common Bile Duct Ligation

Molecules, 2022
During liver fibrogenesis, there is an imbalance between regeneration and wound healing. The current treatment is the withdrawal of the causing agent; thus, investigation of new and effective treatments is important.
Pedro L. R. Guedes, Carolina P. F. Carvalho, Adriana A. F. Carbonel, Manuel J. Simões, Marcelo Y. Icimoto, Jair A. K. Aguiar, Maria Kouyoumdjian, Marcos L. Gazarini, Marcia R. Nagaoka   +8 more
doaj   +1 more source

The use of dietary supplements supporting functioning of musculoskeletal system in rehabilitation clinic patients

Annales Academiae Medicae Silesiensis, 2022
Introduction Musculoskeletal conditions are often characterized by pain, as well as limited physical function. To alleviate pain accompanying musculoskeletal diseases, non-steroidal anti-inflammatory drugs (NSAIDs) and/or paracetamol are used.
Paulina Pluta, Weronika Osmala-Kurpiewska, Agata Piekut   +2 more
doaj   +1 more source

Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2008
Recently, we demonstrated that chondroitin polymerization is achieved by any two combinations of human chondroitin synthase-1 (ChSy-1), ChSy-2 (chondroitin sulfate synthase 3, CSS3), and chondroitin-polymerizing factor (ChPF). Although an additional ChSy family member, called chondroitin sulfate glucuronyltransferase (CSGlcA-T), has been identified ...
Tomomi Izumikawa, Toshiyasu Koike, Shoko Shiozawa, Kazuyuki Sugahara, Jun-ichi Tamura, Hiroshi Kitagawa   +5 more
openaire   +2 more sources

Misincorporation of Galactose by Chondroitin Synthase of Escherichia coli K4: From Traces to Synthesis of Chondbiuronan, a Novel Chondroitin-Like Polysaccharide

Biomolecules, 2020
Chondroitin synthase KfoC is a bifunctional enzyme which polymerizes the capsular chondroitin backbone of Escherichia coli K4, composed of repeated β3N-acetylgalactosamine (GalNAc)-β4-glucuronic acid (GlcA) units. Sugar donors UDP-GalNAc and UDP-GlcA are
Mélanie Leroux, Julie Michaud, Eric Bayma, Sylvie Armand, Sophie Drouillard, Bernard Priem   +5 more
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Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals

Frontiers in Bioengineering and Biotechnology, 2022
Osteoarthritis is a very disabling disease that can be treated with both non-pharmacological and pharmacological approaches. In the last years, pharmaceutical-grade chondroitin sulfate (CS) and glucosamine emerged as symptomatic slow-acting molecules ...
Donatella Cimini, Serena Boccella, Alberto Alfano, Antonietta Stellavato, Salvatore Paino, Chiara Schiraldi, Francesca Guida, Michela Perrone, Maria Donniacuo, Virginia Tirino, Vincenzo Desiderio, Barbara Rinaldi   +11 more
doaj   +1 more source

Symptomatic delayed-acting drugs (SYSADOA): new applications

Современная ревматология, 2022
The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA).
A. M. Lila, E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova   +3 more
doaj   +1 more source