Results 11 to 20 of about 54,528 (266)

Heterologous production of chondroitin [PDF]

Biotechnology Reports, 2022
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound.
Márcia R. Couto, Joana L. Rodrigues, Lígia R. Rodrigues   +2 more
openaire   +6 more sources

Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A [PDF]

Carbohydrate Polymers, 2012
Chondroitin sulfate-E (chondroitin-4, 6-disulfate) was prepared from chondroitin sulfate-A (chondroitin-4 - sulfate) by regioselective sulfonation, performed using trimethylamine sulfur trioxide in formamide under argon. The structure of semi-synthetic chondroitin sulfate-E was analyzed by PAGE, (1)H NMR, (13)C NMR, 2D NMR and disaccharide analysis and
Chao, Cai, Kemal, Solakyildirim, Bo, Yang, Julie M, Beaudet, Amanda, Weyer, Robert J, Linhardt, Fuming, Zhang   +6 more
openaire   +4 more sources

Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill [PDF]

Frontiers in Aging, 2021
Discovering compounds that promote health during aging (“geroprotectors”) is key to the retardation of age-related pathologies and the prevention of chronic age-related diseases. In in-silico and model organisms’ lifespan screens, chondroitin sulfate has
Collin Y. Ewald
doaj   +3 more sources

Endogenous chondroitin extends the lifespan and healthspan in C. elegans [PDF]

Scientific Reports
Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C.
Yukimasa Shibata, Yuri Tanaka, Hiroyuki Sasakura, Yuki Morioka, Toshihiro Sassa, Shion Fujii, Kaito Mitsuzumi, Masashi Ikeno, Yukihiko Kubota, Kenji Kimura, Hidenao Toyoda, Kosei Takeuchi, Kiyoji Nishiwaki   +12 more
doaj   +2 more sources

Chondroitin for osteoarthritis [PDF]

Cochrane Database of Systematic Reviews, 2015
Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review.To evaluate the benefit and harm of oral ...
Jasvinder A, Singh, Shahrzad, Noorbaloochi, Roderick, MacDonald, Lara J, Maxwell   +3 more
openaire   +2 more sources

Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2003
We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. We report
Hiroshi, Kitagawa, Tomomi, Izumikawa, Toru, Uyama, Kazuyuki, Sugahara   +3 more
openaire   +2 more sources

Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis [PDF]

, 2023
Post-traumatic osteoarthritis (PTOA), a disorder of the synovium, subchondral bone, and cartilage that affects the entire joint, constitutes approximately 12% of all cases of symptomatic osteoarthritis.
Dmytro Rekalov, Heorhii Kostenko, Artur Mishchenko, Iryna Golovach, Oleh Ye Akimov, Natalia Solovyova, Viktoriia Kostenko, Vitalii Kostenko   +7 more
core   +1 more source

Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2008
Recently, we demonstrated that chondroitin polymerization is achieved by any two combinations of human chondroitin synthase-1 (ChSy-1), ChSy-2 (chondroitin sulfate synthase 3, CSS3), and chondroitin-polymerizing factor (ChPF). Although an additional ChSy family member, called chondroitin sulfate glucuronyltransferase (CSGlcA-T), has been identified ...
Tomomi Izumikawa, Toshiyasu Koike, Shoko Shiozawa, Kazuyuki Sugahara, Jun-ichi Tamura, Hiroshi Kitagawa   +5 more
openaire   +2 more sources

Chondroitin sulfate [PDF]

, 2022
The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, the mechanism of chondroitin sulfate, a drug for the treatment of ...
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core   +1 more source

Symptomatic delayed-acting drugs (SYSADOA): new applications

Современная ревматология, 2022
The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA).
A. M. Lila, E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova   +3 more
doaj   +1 more source