Results 11 to 20 of about 16,160 (157)

Heterologous production of chondroitin [PDF]

Biotechnology Reports, 2022
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound.
Márcia R. Couto, Joana L. Rodrigues, Lígia R. Rodrigues   +2 more
openaire   +5 more sources

Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A [PDF]

Carbohydrate Polymers, 2012
Chondroitin sulfate-E (chondroitin-4, 6-disulfate) was prepared from chondroitin sulfate-A (chondroitin-4 - sulfate) by regioselective sulfonation, performed using trimethylamine sulfur trioxide in formamide under argon. The structure of semi-synthetic chondroitin sulfate-E was analyzed by PAGE, (1)H NMR, (13)C NMR, 2D NMR and disaccharide analysis and
Chao, Cai, Kemal, Solakyildirim, Bo, Yang, Julie M, Beaudet, Amanda, Weyer, Robert J, Linhardt, Fuming, Zhang   +6 more
openaire   +3 more sources

Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill [PDF]

Frontiers in Aging, 2021
Discovering compounds that promote health during aging (“geroprotectors”) is key to the retardation of age-related pathologies and the prevention of chronic age-related diseases. In in-silico and model organisms’ lifespan screens, chondroitin sulfate has
Collin Y. Ewald
doaj   +2 more sources

Endogenous chondroitin extends the lifespan and healthspan in C. elegans

Scientific Reports
Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C.
Yukimasa Shibata, Yuri Tanaka, Hiroyuki Sasakura, Yuki Morioka, Toshihiro Sassa, Shion Fujii, Kaito Mitsuzumi, Masashi Ikeno, Yukihiko Kubota, Kenji Kimura, Hidenao Toyoda, Kosei Takeuchi, Kiyoji Nishiwaki   +12 more
doaj   +2 more sources

Interaction of Chondroitin and Hyaluronan Glycosaminoglycans with Surfaces of Carboxylated Carbon Nanotubes Studied Using Molecular Dynamics Simulations

Molecules, 2023
Interaction of β-D-glucopyranuronic acid (GlcA), N-acetyl-β-D-glucosamine (GlcNAc), N-acetyl-β-D-galactosamine (GalNAc) and two natural decameric glycosaminoglycans, hyaluronic acid (HA) and Chondroitin (Ch) with carboxylated carbon nanotubes, were ...
Tomasz Panczyk, Wojciech Plazinski, François-Yves Dupradeau, Agnieszka Brzyska, Pawel Wolski   +4 more
doaj   +1 more source

Enzymatic Production of Chondroitin Oligosaccharides and Its Sulfate Derivatives

Frontiers in Bioengineering and Biotechnology, 2022
Chondroitin sulfate (CS) has a wide range of physiological functions and clinical applications. However, the biosynthesis of chondroitin oligosaccharides (o-CHs) and sulfate derivatives with specific length is always challenging.
Weijiao Zhang, Weijiao Zhang, Weijiao Zhang, Ruirui Xu, Ruirui Xu, Xuerong Jin, Xuerong Jin, Yang Wang, Yang Wang, Litao Hu, Litao Hu, Tianmeng Zhang, Tianmeng Zhang, Guocheng Du, Guocheng Du, Zhen Kang, Zhen Kang   +16 more
doaj   +1 more source

Gastroprotective Effects of Oral Glycosaminoglycans with Sodium Alginate in an Indomethacin-Induced Gastric Injury Model in Rats

Veterinary Sciences, 2023
The gastrointestinal (GI) mucosal barrier is often exposed to inflammatory and erosive insults, resulting in gastric lesions. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), chondroitin sulfate (CS), and N-acetylglucosamine (NAG) have shown ...
Sara Traserra, Héctor Cuerda, Adriana Vallejo, Sergi Segarra, Roger Sabata, Marcel Jimenez   +5 more
doaj   +1 more source

Osteoarthritis background therapy: current view on the glucosamine and chondroitin therapy

Современная ревматология, 2021
The article highlights the current status of symptomatic slow-acting drugs (SYSADOA) in osteoarthritis (OA). Mechanism of action, clinical studies data on the effectiveness of glucosamine (GA) and chondroitin sulfate (CS) and their combinations in OA ...
L. I. Alekseeva, A. M. Lila
doaj   +1 more source

Chondroitin for osteoarthritis [PDF]

Cochrane Database of Systematic Reviews, 2015
Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review.To evaluate the benefit and harm of oral ...
Jasvinder A, Singh, Shahrzad, Noorbaloochi, Roderick, MacDonald, Lara J, Maxwell   +3 more
openaire   +2 more sources

Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthritis and nonspecific back pain

Современная ревматология, 2023
The combined use of drugs with different mechanisms of action is the main principle of musculoskeletal pain control in rheumatic diseases. However, there are few studies evaluating the efficacy of this approach in real practice.Objective: to determine ...
A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, S. A. Yanchenkova   +37 more
doaj   +1 more source