Results 11 to 20 of about 60,461 (205)
Heterologous production of chondroitin [PDF]
Biotechnology Reports, 2022 Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound.
Márcia R. Couto +2 more
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Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A [PDF]
Carbohydrate Polymers, 2012 Chondroitin sulfate-E (chondroitin-4, 6-disulfate) was prepared from chondroitin sulfate-A (chondroitin-4 - sulfate) by regioselective sulfonation, performed using trimethylamine sulfur trioxide in formamide under argon. The structure of semi-synthetic chondroitin sulfate-E was analyzed by PAGE, (1)H NMR, (13)C NMR, 2D NMR and disaccharide analysis and
Chao, Cai +6 more
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Chondroitin Sulfate and Its Derivatives: A Review of Microbial and Other Production Methods
Fermentation, 2022 Chondroitin sulfate (CS) is widely used across the world as a nutraceutical and pharmaceutical. Its high demand and potential limitations in current methods of extraction call for an alternative method of production.
Adeola E. Awofiranye +5 more
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Heliyon, 2023 N-Acetylheparosan and chondroitin are increasingly needed as alternative sources of animal-derived sulfated glycosaminoglycans (GAGs) and as inert substances in medical devices and pharmaceuticals. The N-acetylheparosan productivity of E.
Kiyoshi Suzuki, Hiromi Kaseyama-Takemoto
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Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill [PDF]
Frontiers in Aging, 2021 Discovering compounds that promote health during aging (“geroprotectors”) is key to the retardation of age-related pathologies and the prevention of chronic age-related diseases. In in-silico and model organisms’ lifespan screens, chondroitin sulfate has
Collin Y. Ewald
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Endogenous chondroitin extends the lifespan and healthspan in C. elegans
Scientific ReportsChondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C.
Yukimasa Shibata +12 more
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The Journal of Organic Chemistry, 2019 Chondroitin sulfate (CS) is a structurally complex polyanionic glycosaminoglycan that plays essential roles in physiological processes. Here we report a facile approach to a library of CS tetra- and hexasaccharides based on the enzymatic degradation of chondroitin over 10 or 11 steps, which is the shortest synthetic route toward size-defined CS ...
Xiao Zhang +4 more
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Chondroitin for osteoarthritis [PDF]
Cochrane Database of Systematic Reviews, 2015 Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review.To evaluate the benefit and harm of oral ...
Jasvinder A, Singh +3 more
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Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization [PDF]
Journal of Biological Chemistry, 2003 We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. We report
Hiroshi, Kitagawa +3 more
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Symptomatic delayed-acting drugs (SYSADOA): new applications
Современная ревматология, 2022 The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA).
A. M. Lila +3 more
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