Results 281 to 290 of about 93,694 (356)

The Sweet Aspects of Orthoflavivirus Treatment Design and Vaccine Development

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Viruses in the genus Orthoflavivirus are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad‐spectrum treatments and preventive measures for these viral infections in humans.
Ana C. Alcalá, Michelle Gutiérrez, Juan E. Ludert   +2 more
wiley   +1 more source

Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine

Macromolecular Bioscience, Volume 25, Issue 10, October 2025.
This review analyses multifunctional injectable hydrogels, natural or synthetic, physically or chemically crosslinked, that deliver exosomes, stem cells, and other bioactive cues to inflamed or damaged oral tissues. We discuss their immunomodulatory, antimicrobial, angiogenic, and osteogenic capacities, highlighting advances that enable regenerative ...
Renan Dal‐Fabbro, Arwa Daghrery, Caroline Anselmi, Igor Paulino M. Soares, Alexandre Henrique dos Reis‐Prado, Pedro Henrique Chaves de Oliveira, Marco C. Bottino   +6 more
wiley   +1 more source

Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
Regarding the general picture of heart regeneration therapy, it encompasses exogenous cell therapy, endogenous medications, metabolism, interventions in gene pathways, as well as the therapeutic strategies in the burgeoning interdisciplinary field of medicine and engineering in recent years.
Mingchuan Liu, Tingwei Peng, Rui Yu, Kexin Wang, Di Wang, Xiaojie Jia, Yan Zhang, Jianqiang Hu, Bingchao Qi, Yan Li   +9 more
wiley   +1 more source

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications

MedComm, Volume 6, Issue 10, October 2025.
Schematic diagram illustrating the comprehensive landscape of hydrogel microspheres (HMs). (A) The components of HMs. (B) Preparation technologies employed in fabricating HMs. (C) The diverse applications of HMs across different fields. (D) The therapeutic applications of HMs in the treatment of various systemic diseases, demonstrating their potential ...
Meng Yang, Yuanyuan Shi, Feng Wang, Xin Zhang, Jiayi Shao, Fan Yang, Hao Sun, Chong Zhang, Zheng Zhou, Jianyong Huang, Pengyu Lv, Patrick Shu‐Hang Yung, Jin Cheng, Hong‐Jie Huang, Jian‐Quan Wang   +14 more
wiley   +1 more source

Molecular Evolution and Gene Diversity of Dermatan Sulfate Sulfotransferases in Ascidians

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT Ascidians (Chordata, Tunicata) are model organisms for studying molecules, particularly sulfated glycosaminoglycans (GAGs), due to their phylogenetic proximity to vertebrates and unique GAG variants. Over‐sulfated dermatan sulfate (DS) contributes to proteoglycan diversity and cellular processes in metazoans.
Vanessa de Sousa Rizzo‐Valente, Mauro S. G. Pavão   +1 more
wiley   +1 more source

The Glycosaminoglycan‐Dependent Interactome of Neurexin‐1 in Human Fetal Glial Cells

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT Neurexins are synaptic adhesion molecules best characterized in neurons, where they regulate synapse assembly and function, with emerging evidence indicating they are also abundantly expressed by astrocytes. To elucidate the interactome of NRXN1α, we employed a proximity labeling strategy in cultured human fetal glial cells (SVG p12 cells ...
Meg Critcher, Han Wu, Yajing Lu, Mia L. Huang   +3 more
wiley   +1 more source

"Good" fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis. [PDF]

Signal Transduct Target Ther
Choi DW, Lee EW.
europepmc   +1 more source

The Glycocalyx: Barriers and Opportunities at Cell–Cell Encounters

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT The glycocalyx, a carbohydrate‐rich, gel‐like layer that coats every mammalian cell, is the first point of contact between cells in tissues. It therefore critically influences these encounters, impacting their mechanical, electrical, and chemical features that ultimately determines the outcome of cell–cell contacts.
Lucas C. Wyss, Spencer A. Freeman
wiley   +1 more source

Modulation of electrical activity of proteinoid microspheres with chondroitin sulfate clusters. [PDF]

PLoS One
Mougkogiannis P, Adamatzky A.
europepmc   +1 more source

Synthetic Biology and Biomaterials Strategies to Deceive the Tumor Microenvironment in CAR‐T Immunotherapy

Small, Volume 21, Issue 39, October 2, 2025.
A. Synthetic biology and biomaterials have emerged as tools to study and facilitate the treatment of solid tumors wi‐th chimeric antigen receptor‐CAR‐T cells. These strategies aim to resist the tumor microenvironment‐TME that presents cellular, biochemical, and mechanical immunosuppressive signals that hinder CAR‐T efficacy. B.
Grazia Marsico, Sudarshan GC, Velia Siciliano   +2 more
wiley   +1 more source