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Microbial production and metabolic engineering of chondroitin and chondroitin sulfate
Emerging Topics in Life Sciences, 2018Several commercial uses and potential novel applications have recently been described for chondroitin sulfate (CS). However, the currently applied animal extractive procedure has a high environmental impact, which may become more profound especially in relation to the forecasted expansion of the CS market for applications as a food supplement ...
Cimini D., Restaino O. F., Schiraldi C.
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Glucosamine and Chondroitin Sulfate [PDF]
Rheumatic Disease Clinics of North America, 2011 Glucosamine and chondroitin sulfate, components of normal cartilage that are marketed as dietary supplements in the United States, have been evaluated for their potential role in the treatment of osteoarthritis. Due to claims of efficacy, increased prevalence of osteoarthritis, and a lack of other effective therapies, there has been substantial ...
Daniel O. Clegg +2 more
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Chondroitin as metabolic precursor of chondroitin sulfate in bovine cornea
Experimental Eye Research, 1972Abstract The low sulfated chondroitin sulfate fraction isolated and purified from bovine cornea was shown to consist of numerous molecular species ranging in their sulfate-hexosamine ratio from 0·2 – 0·9. On incubation of cornea in vitro, under appropriate conditions in the presence of 35S-sulfate, all chondroitin sulfates were obtained in the 35S ...
Eckhart Buddecke, H. Bleckmann
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Isomeric Chondroitin Sulphates
Nature, 1958A RECENT communication1 claims to “confirm Meyer's hypothesis that chondroitin sulphates A and C are only two fractions of the same polydisperse substance”. Apparent lack of agreement in nomenclature2–4 further emphasizes the need for clear differentiation of the isomeric chondroitin sulphates of connective tissue.
Martin B. Mathews, Martin B. Mathews
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Macromolecular assembly of chondroitin
Biochemical and Biophysical Research Communications, 1972Abstract A microsomal preparation from chick embryo epiphyseal cartilage has been used to study the assembly of the heteropolysaccharide, chondroitin. Endogenous chondroitin sulfate in the microsomal preparation was found to act as a primer for the addition of relatively short non-sulfated polysaccharide chains to form large molecules with a large ...
Jeremiah E. Silbert +2 more
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2003
In the 1950s, in vitro studies of glucosamine demonstrated its potential to increase fibroblast production of collagen and mucopolysaccharides. These findings led to studies of glucosamine for the treatment of osteoarthritis (OA) in humans, first with an injectable product, and then with oral supplementation (McCarty, 1994).
Timothy S. Tracy, Melanie Johns Cupp
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In the 1950s, in vitro studies of glucosamine demonstrated its potential to increase fibroblast production of collagen and mucopolysaccharides. These findings led to studies of glucosamine for the treatment of osteoarthritis (OA) in humans, first with an injectable product, and then with oral supplementation (McCarty, 1994).
Timothy S. Tracy, Melanie Johns Cupp
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[34] Microsomal sulfation of proteochondroitin, chondroitin, and chondroitin oligosaccharides
1989Publisher Summary This chapter focuses on the microsomal sulfation of proteochondroitin, chondroitin, and chondroitin oligosaccharides. Chondroitin sulfate—a polymer of gIucuronic acid (GlcA) and N-acetyl galactosamine (GalNAc)—can be sulfated on either or both the 4 and 6 positions of the GalNAc and on the 2 position of the GlcA. Chondroitin sulfate
Donald E. Humphries +2 more
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The biosynthesis of chondroitin sulfate
Archives of Biochemistry and Biophysics, 1966Abstract A particulate enzyme preparation from embryonic chick cartilage catalyzes incorporation of radioactivity from UDP-GalNAc- 3 H or UDP-Glc-UA- 14 C into chondroitin sulfate. In the absence of added oligosaccharide acceptor, incorporation of radioactivity from either nucleotide required the presence of the alternate unlabeled nucleotide ...
Alvin Telser +2 more
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Journal of Molecular Structure: THEOCHEM, 2004
Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
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Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
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Structure of Chondroitin Sulfate
2006Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Nikos K. Karamanos, Fotini N. Lamari
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