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Production of chondroitin sulfate and chondroitin
Applied Microbiology and Biotechnology, 2010The production of microbial polysaccharides has recently gained much interest because of their potential biotechnological applications. Several pathogenic bacteria are known to produce capsular polysaccharides, which provide a protection barrier towards harsh environmental conditions, and towards host defences in case of invasive infections.
SCHIRALDI, Chiara +2 more
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Journal of Molecular Structure: THEOCHEM, 2004
Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Halil Bayraktar +3 more
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Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Halil Bayraktar +3 more
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Journal of Consumer Health On the Internet, 2006
Results of the four-year study entitled the Glucosamine/ chondroitin Arthritis Intervention Trial (GAIT) provided partial answers to those seeking relief from arthritis pain. Scientists will continue studying the efficacy of these substances as pain remedy and cartilage rejuvenator.
Suzanne M. Shultz, Esther Y. Dell
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Results of the four-year study entitled the Glucosamine/ chondroitin Arthritis Intervention Trial (GAIT) provided partial answers to those seeking relief from arthritis pain. Scientists will continue studying the efficacy of these substances as pain remedy and cartilage rejuvenator.
Suzanne M. Shultz, Esther Y. Dell
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Isomeric Chondroitin Sulphates
Nature, 1958A RECENT communication1 claims to “confirm Meyer's hypothesis that chondroitin sulphates A and C are only two fractions of the same polydisperse substance”. Apparent lack of agreement in nomenclature2–4 further emphasizes the need for clear differentiation of the isomeric chondroitin sulphates of connective tissue.
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Macromolecular assembly of chondroitin
Biochemical and Biophysical Research Communications, 1972Abstract A microsomal preparation from chick embryo epiphyseal cartilage has been used to study the assembly of the heteropolysaccharide, chondroitin. Endogenous chondroitin sulfate in the microsomal preparation was found to act as a primer for the addition of relatively short non-sulfated polysaccharide chains to form large molecules with a large ...
M E, Richmond, S, DeLuca, J E, Silbert
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Glucosamine and Chondroitin Sulfate
Rheumatic Disease Clinics of North America, 2011Glucosamine and chondroitin sulfate, components of normal cartilage that are marketed as dietary supplements in the United States, have been evaluated for their potential role in the treatment of osteoarthritis. Due to claims of efficacy, increased prevalence of osteoarthritis, and a lack of other effective therapies, there has been substantial ...
Karla L, Miller, Daniel O, Clegg
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Sequential synthesis of chondroitin oligosaccharides by immobilized chondroitin polymerase mutants
Glycoconjugate Journal, 2008Escherichia coli strain K4 expresses a chondroitin (CH)-polymerizing enzyme (K4CP) that contains two glycosyltransferase active domains. K4CP alternately transfers glucuronic acid (GlcA) and N-acetyl-galactosamine (GalNAc) residues using UDP-GlcA and UDP-GalNAc donors to the nonreducing end of a CH chain acceptor.
Nobuo, Sugiura +5 more
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Structure of Chondroitin Sulfate
2006Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Fotini N, Lamari, Nikos K, Karamanos
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Biosynthesis of Chondroitin Sulphates
Nature, 1959LITTLE information is available regarding the biosynthesis of acid mucopolysaccharides. Knowledge of biosynthetic pathways to the chondroitin sulphates in particular is practically confined to the fact that glucose is utilized for both the hexosamine and uronic acid moieties1 and that 3′—phosphoadenosine 5′—phosphosulphate (PAPS) is involved in ...
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