Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]
BMC Cancer, 2018 Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Castañón de la Torre, Sonia +6 more
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End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans [PDF]
Chemical Science, 2010 Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration.
Brown, Joshua M. +6 more
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Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]
Journal of Biological Chemistry, 2008 Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Vy M. Tran +4 more
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NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans [PDF]
Nature Neuroscience, 2012 In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition.
Herbert M. Geller +14 more
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CD44 binds a chondroitin sulfate proteoglycan, aggrecan [PDF]
International Immunology, 2001 Here we report that CD44 binds a chondroitin sulfate (CS) proteoglycan, aggrecan, a major component of cartilage. Soluble CD44-IgG and CD44(+) cells bound to aggrecan from rat chondrosarcoma and bovine cartilage, immobilized on microtiter plates. In both cases, binding was blocked by a neutralizing anti-CD44 mAb or by the pretreatment of aggrecan with ...
Hiroto Kawashima +6 more
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Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]
, 2006 Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R +4 more
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大腸菌を用いたフォスファカン（コンドロイチン硫酸プロテオグリカン）の融合コア蛋白の発現条件の検討 [PDF]
, 1996 Optimal conditions for expressing a specific region of core protein of phosphacan, a chondroitin sulfate proteoglycan known as receptor type protein tyrosine phosphatase, as fusion protein with glutathione S-transferase (GST) in E.coli were examined. DNA
Ito, Sekiko, Okamoto, Motoi
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Regulation of Synthesis of Chondroitin Sulfate Proteoglycan [PDF]
Upsala Journal of Medical Sciences, 1977 (1977). Regulation of Synthesis of Chondroitin Sulfate Proteoglycan. Upsala Journal of Medical Sciences: Vol. 82, No. 2, pp. 76-77.
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Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial. [PDF]
, 2011 Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite extension through chondroitin sulfate-rich matrices and
Butterfield, Karen Chao +2 more
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Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans [PDF]
Osteoarthritis and Cartilage, 2010 The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may also have therapeutic interest in diseases of the central nervous system (CNS). We review here such evidence.
Manuela G. López +4 more
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