M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury [PDF]
Neural Regeneration Research, 2022 After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon ...
Shui-Sheng Yu +8 more
doaj +3 more sources
An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination [PDF]
Nature Communications, 2016 Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate ...
Michael B Keough +2 more
exaly +4 more sources
Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction [PDF]
eLife, 2022 Sympathetic denervation of the heart following ischemia/reperfusion induced myocardial infarction (MI) is sustained by chondroitin sulfate proteoglycans (CSPGs) in the cardiac scar. Denervation predicts risk of sudden cardiac death in humans.
Matthew R Blake +5 more
doaj +3 more sources
Role of Chondroitin Sulfate Proteoglycan 5 in Steroid-Induced Cataract [PDF]
Cells, 2023 Steroid-induced cataracts (SIC) are defined as cataracts associated with the administration of corticosteroids. Long-term glucocorticoid treatment for inflammatory diseases reportedly increases the risk of SIC, and steroids can induce cataracts by ...
Woong-Sun Yoo +8 more
doaj +2 more sources
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy [PDF]
Science Translational Medicine, 2018 Serena Pellegatta +2 more
exaly +3 more sources
Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment. [PDF]
J Neurosci, 2018 Chondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic neurogenesis. The aim of this study was to specify the functional significance of CSPG in adult hippocampal neurogenesis using male mice. Here, we showed that neural stem cells
Yamada J +4 more
europepmc +2 more sources
Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types. [PDF]
Front Immunol, 2017 Overexpression of the chondroitin sulfate proteoglycan 4 (CSPG4) has been associated with the pathology of multiple types of such as melanoma, breast cancer, squamous cell carcinoma, mesothelioma, neuroblastoma, adult and pediatric sarcomas, and some ...
Ilieva KM +11 more
europepmc +2 more sources
Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. [PDF]
Oncotarget, 2017 Neurocan (NCAN), a secreted chondroitin sulfate proteoglycan, is one of the major inhibitory molecules for axon regeneration in nervous injury. However, its role in cancer is not clear.
Su Z +11 more
europepmc +2 more sources
SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer. [PDF]
PLoS ONE, 2012 SRPX2 (Sushi repeat-containing protein, X-linked 2) has recently emerged as a multifunctional protein that is involved in seizure disorders, angiogenesis and cellular adhesion. Here, we analyzed this protein biochemically. SRPX2 protein was secreted with
Kaoru Tanaka +14 more
doaj +2 more sources
Pattern of chondroitin sulfate proteoglycan expression after ablation of the sensorimotor cortex of the neonatal and adult rat brain [PDF]
Archives of Biological Sciences, 2008 The central nervous system has a limited capacity for self-repair after damage. However, the neonatal brain has agreater capacity for recovery than the adult brain.
Dacić Sanja +6 more
doaj +3 more sources